基因组学与应用生物学

参考文献

Bai Q.,Garver J.A.,Hukriede N.A.,and Burton E.A.,2007,Generation of a transgenic zebrafish model of tauopathy using a novel promoter element derived from the zebrafish eno2gene,Nucleic Acids Res.,35(19):6501-6516

Berger Z.,Ravikumar B.,Menzies F.M.,Oroz L.G.,Underwood B.R.,Pangalos M.N.,Schmitt I.,Wullner U.,Evert B.O.,O'Kane C.J.,and Rubinsztein D.C.,2006,Rapamycin alleviates toxicity of different aggregate-prone proteins,Hum.Mol.Genet.,15(3):433-442

Boglev Y.,Badrock A.P.,Trotter A.J.,Du Q.,Richardson E.J.,Parslow A.C.,Markmiller S.J.,Hall N.E.,de Jong-Curtain T.A.,Ng A.Y.,Verkade H.,Ober E.A.,Field H.A.,Shin D.,Shin C.H.,Hannan K.M.,Hannan R.D.,Pearson R.B.,Kim S.H.,Ess K.C.,Lieschke G.J.,Stainier D.Y.,and Heath J.K.,2013,Autophagy induction is a Tor-and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis,PLoS Genet.,9(2):1003279

Ding Y.,Sun X.,Redfield M.,Kushwaha S.,and Xu X.,2012,Target of rapamcyin(TOR)-based therapeutics for cardiomyopathy:insights from zebrafish genetics,Cell Cycle,11(3):428-429

Faas F.G.,Avramut M.C.,Van den Berg B.M.,Mommaas A.M.,Koster A.J.,and Ravelli R.B.,2012,Virtual nanoscopy:generation of ultra-large high resolution electron microscopy maps,J.Cell Biol.,198(3):457-469

Feng H.,Stachura D.L.,White R.M.,Gutierrez A.,Zhang L.,Sanda T.,Jette C.A.,Testa J.R.,Neuberg D.S.,Langenau D.M.,Kutok J.L.,Zon L.I.,Traver D.,Fleming M.D.,Kanki J.P.,and Look A.T.,2010,T-lymphoblastic lymphoma cells express high levels of BCL2,S1P1,and ICAM1,leading to a blockade of tumor cell intravasation,Cancer Cell,18(4):353-366

Fleming A.,and Rubinsztein D.C.,2011,Zebrafish as a model to understand autophagy and its role in neurological disease,Biochim.Biophys.Acta,1812(4):520-526

George A.A.,Hayden S.,Holzhausen L.C.,Ma E.Y.,Suzuki S.C.,and Brockerhoff S.E.,2014,Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments,PLoS One,9(1):84394

Gibbs E.M.,Feldman E.L.,and Dowling J.J.,2010,The role of MTMR14 in autophagy and in muscle disease,Autophagy,6(6):819-820

Hart P.D.,and Young M.R.,1991,Ammonium chloride,an inhibitor of phagosome-lysosome fusion in macrophages,concurrently induces phagosome-endosome fusion,and opens a novel pathway:studies of a pathogenic mycobacterium and a nonpathogenic yeast,J.Exp.Med.,174(4):881-889

He C.,and Klionsky D.J.,2010,Analyzing autophagy in zebrafish,Autophagy,6(5):642-644

He C.,and Levine B.,2010,The beclin 1 interactome,Curr.Opin.in Cell Biol.,22(2):140-149

He C.,Bartholomew C.R.,Zho u W.,and Klionsky D.J.,2009,Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos,Autophagy,5(4):520-526

Johansen T.,and Lamark T.,2011,Selective autophagy mediated by autophagic adapter proteins,Autophagy,7(3):279-296

Klionsky D.J.,2008,Autophagy revisited:a conversation with Christian de Duve,Autophagy,4(6):740

Kondratskyi A.,Yassine M.,Kondratska K.,Skryma R.,Slomianny C.,and Prevarskaya N.,2013,Calcium-permeable ion channels in control of autophagy and cancer,Front.Physiol.,4:272

Langenau D.M.,Traver D.,Ferrando A.A.,Kutok J.L.,Aster J.C.,Kanki J.P.,Lin S.,Prochownik Ed.,Trede N.S.,Zon L.I.,Look A.T.,2003,Myc-induced T cell leukemia in transgenic zebrafish,Science,299(5608):887-890

Levine B.,Liu R.,Dong X.,and Zhong Q.,2015,Beclin orthologs:integrative hubs of cell signaling,membrane trafficking,and physiology,Trends Cell Biol.,25(9):533-544

Marin T.M.,Keith K.,Davies B.,Conner D.A.,Guha P.,Kalaitzidis D.,Wu X.,Lauriol J.,Wang B.,Bauer M.,Bronson R.,Franchini K.G.,Neel B.G.,and Kontaridis M.I.,2011,Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11mutation,J.Clin.Inves.,121(3):1026-1043

Mcmullen J.R.,Sherwood M.C.,Tarnavski O.,Zhang L.,Dorfman A.L.,Shioi T.,and Izumo S.,2004,Inhibition of m TORsignaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload,Circulation,109(24):3050-3055

Menzies F.M.,Huebener J.,Renna M.,Bonin M.,Riess O.,and Rubinsztein D.C.,2009,Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3,Brain,133(1):93-104

Mizushima N.,and Komatsu M.,2011,Autophagy:renovation of cells and tissues,Cell,147(4):728-741

Nagy P.,Hegedüs K.,Pircs K.,Varga魣.,and Juhász G.,2014,Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila,FEBS Lett.,588(3):408-413

Ohsumi Y.,and Mizushima N.,2004,Two ubiquitin-like conjugation systems essential for autophagy,Semin.Cell Dev.Biol.,15(2):231-236

Otomo C.,Metlagel Z.,Takaesu G.,and Otomo T.,2013,Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy,Nat.Struct.Mol.Biol.,20(1):59-66

Paquet D.,Bhat R.,Sydow A.,Mandelkow E.,Berg S.,Hellberg S.,F觟lting J.,Distel M.,K觟ster R.W.,Schmid B.,and Haass C.,2009,A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation,J.Clin.Invest.,119(5):1382-1395

Ramesh T.,Lyon A.N.,Pineda R.H.,Wang C.,Janssen P.M.,Canan B.D.,Burghes A.H.,and Beattie C.E.,2010,A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease,Dis.Model.Mech.,3(9-10):652-662

Ravikumar B.,Duden R.,and Ru binsztein D.C.,2002,Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy,Hum.Mol.Genet.,11(9):1107-1117

Ravikumar B.,Vacher C.,Berger Z.,Davies J.E.,Luo S.,Oroz L.G.,Scaravilli F.,Easton D.F.,Duden R.,O'Kane C.J.,and Rubinsztein D.C.,2004,Inhibition of m TOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease,Nat.Genet.,36(6):585-595

Rubinsztein D.C.,Gestwicki J.E.,Murphy L.O.,and Klionsky D.J.,2007,Potential therapeutic applications of autophagy,6(4):304-312

Russell R.C.,Yuan H.X.,and Guan K.L.,2014,Autophagy regulation by nutrient signaling,Cell Res.,24(1):42-57

Sasaki T.,Lian S.,Qi J.,Bayliss P.E.,Carr C.E.,Johnson J.L.,Guha S.,Kobler P.,Catz S.D.,Gill M.,Jia K.,Klionsky D.J.,and Kishi S.,2014,Aberrant autolysosomal regulation is linked to the induction of embryonic senescence:differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency,PLoS Genet.,10(6):1004409

Shioi T.,Mcmullen J.R.,Tarnavski O.,Converso K.,Sherwood M.C.,Manning W.J.,and Izumo S.,2003,Rapamycin attenuates load-induced cardiac hypertrophy in mice,Circulation,107(12):1664-1670

Tomasiewicz H.G.,Flaherty D.B.,Soria J.P.,and Wood J.G.,2002,Transgenic zebrafish model of neurodegeneration,J.Neurosc.Res.,70(6):734-745

Underwood B.R.,Imarisio S.,Fleming A.,Rose C.,Krishna G.,Heard P.,Quick M.,Korolchuk V.I.,Renna M.,Sarkar S.,Garca-Arencibia M.,O'Kane C.J.,Murphy M.P.,and Rubinsztein D.C.,2010,Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease,Hum.Mol.Genet.,19(17):3413-3429

Varga M.,Fodor E.,and Vellai T.,2015,Autophagy in zebrafish,Methods,75:172-180

Varga M.,Sass M.,Papp D.,Taka'cs-Vellai K.,Kobolak J.,Dinnye's A.,Klionsky D.J.,and Vellai T.,2014,Autophagy is required for zebrafish caudal fin regeneration,Cell Death Differ,21(4):547-556

Williams A.,Sarkar S.,Cuddon P.,Ttofi E.K.,Saiki S.,Siddiqi F.H.,Jahreiss L.,Fleming A.,Pask D.,Goldsmith P.,O'Kane C.J.,Floto R.A.,and Rubinsztein D.C.,2008,Novel targets for Huntington's disese in an m TOR-independent autophagy pathway,Nature Chemical Biology,4(5):295-305

Yamada Y.,Suzuki N.N.,Hanada T.,Ichimura Y.,Kumeta H.,Fujioka Y.,Ohsumi Y.,and Inagaki F.,2007,The crystal structure of Atg3,an autophagy-related ubiquitin carrier protein(E2)enzyme that mediates Atg8 lipidation,J.Biol.Chem.,282(11):8036-8043

Zhu H.,Rothermel B.A.,and Hill J.A.,2009,Autophagy in load-induced heart disease,Methods Enzymol.,453(12):343-363