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耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus, MRSA)是一类重要的人畜共患病原菌,在全球范围内引起了相当高的发病率和死亡率。运用有效、可靠的分子分型技术对MRSA的分子流行病学特征进行调查分析,将非常有助于MRSA感染性疾病的防控和治疗。本研究对MRSA的多种分子分型技术的原理和方法学评价以及流行现状进行了概述,为MRSA的分子流行病学研究提供了一定的参考依据;本研究指出每种分型方法都有其特有的分型优势,同时又具有分型限制性。在对MRSA菌株进行分型分析时,应该根据现实需要选择多种分型方法对菌株进行多方位研究,保证分型结果的可靠性,为MRSA的分子流行病学分析提供更加准确详实的依据。
Abstract：Methicillin-resistant Staphylococcus aureus(MRSA) is an important zoonotic pathogen that causes considerable morbidity and mortality worldwide. Using effective and reliable molecular typing techniques to investigate the molecular epidemiological characteristics of MRSA will be very helpful in the prevention and treatment of MRSA infectious diseases. In this study, the principle and methodological evaluation of various molecular typing techniques of MRSA and the prevalence of MRSA are summarized, which provides some reference foundation for the molecular epidemiological study of MRSA; This study indicated that every typing method has its unique advantage, but also has a restrictive of typing. In the typing analysis of MRSA strains,multiple typing methods should be selected according to the actual need of the strains to conduct multi-directional research to ensure the reliability of typing results, providing more accurate and detailed basis for molecular epidemiological analysis of MRSA.
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基本信息:
DOI：10.13417/j.gab.038.005509
中图分类号:R446.5
引用信息:
[1]陈程,常佳伟,万佳宏,等.耐甲氧西林金黄色葡萄球菌的分子分型及流行现状[J].基因组学与应用生物学,2019,38(12):5509-5515.DOI:10.13417/j.gab.038.005509.
基金信息:
国家自然科学资金项目(31360626)资助
2019-12-25
2019-12-25