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为探究轻度认知功能障碍(MCI)患者中医证候的特点以及与血清脑源性神经营养因子(BDNF)水平的关系。本研究根据轻度认知障碍的诊断标准,在社区中随机筛选出MCI患者120例,正常对照组60例,比较两组人群的中医证候,并采用双抗体夹心ABC-ELISA法检测MCI患者血清BDNF水平。结果显示,MCI患者中医体质平和质34例(28.33%),偏颇体质中以阳虚质及气虚质为主。在中医辨证分型中,以脾肾亏虚证52例(43.33%)、气血不足证18例(15.00%)为主。MCI患者的血清BDNF水平较正常对照组显著升高(p<0.05),MCI患者中脾肾亏虚证血清BDNF水平显著低于非脾肾亏虚证血清BDNF水平(p<0.05)。本研究表明MCI在肾、脾、心三脏虚损的基础上,兼有痰、淤等邪,提示MCI为本虚标实之证。MCI患者的血清BDNF水平较正常对照组显著降低,且脾肾亏虚证血清BDNF水平显著低于非脾肾亏虚证血清BDNF水平,提示血清中BDNF水平与轻度认知功能障碍疾病的发生、发展密切相关,脾肾亏虚证患者能够通过温阳益气、健脾补肾来改善脑内BDNF水平,从而改善认知功能,符合中医治未病思路。
Abstract：In order to explore the characteristics of TCM syndromes in patients with mild cognitive impairment(MCI) and its relationship with serum brain-derived neurotrophic factor(BDNF) levels, according to the diagnostic criteria of mild cognitive impairment, 120 patients with MCI were randomly selected from the community, and 60 patients in the normal control group. The TCM syndromes of the two groups were compared.The serum BDNF levels in MCI patients were detected by double antibody sandwich ABC-ELISA. The results showed that 34 cases(28.33%) of MCI patients with physique and physique were mainly yang deficiency and qi deficiency. In the syndrome differentiation of TCM, 52 cases(43.33%) of spleen and kidney deficiency syndrome and 18 cases(15.00%) of qi and blood deficiency syndrome were the main. The serum BDNF level of patients with MCI was significantly higher than that of the normal control group(p<0.05). The serum BDNF level of MCI patients was significantly lower than that of non-spleen kidney deficiency syndrome(p<0.05). This study shows that MCI is based on the deficiency of kidney, spleen and heart, and has both sputum and silt, suggesting that MCI is the evidence of virtual standard. The serum BDNF level of patients with MCI was significantly lower than that of the normal control group, and the serum BDNF level of spleen and kidney deficiency syndrome was significantly lower than that of non-spleen kidney deficiency syndrome serum, suggesting that BDNF level and mild cognitive impairment occurred in serum. The development is closely related. Patients with spleen and kidney deficiency syndrome could improve the brain BDNF level through Wenyang Yiqi and spleen and kidney, thus improving cognitive function and conforming to the idea of treating traditional Chinese medicine.
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基本信息:
DOI：10.13417/j.gab.037.004655
中图分类号:R277.7
引用信息:
[1]裴瑜,张明,张洁,等.轻度认知功能障碍中医证候特点及与血清BDNF水平的初步研究[J].基因组学与应用生物学,2018,37(10):4655-4662.DOI:10.13417/j.gab.037.004655.
基金信息:
浦东新区中医青年骨干培养项目资助(No:PDZYXK-5-2014016)资助
2018-10-25
2018-10-25