| 1,792 | 42 | 116 |
| 下载次数 | 被引频次 | 阅读次数 |
植物提取物鞣花酸是广泛存在于多种植物中的重要生物活性物质之一,阐述其药理作用、提取分离纯化及制剂研究具有非常重要的现实意义。本研究通过查阅近年来国内外文献,研究表明植物提取物鞣花酸具有抗氧化、抗肿瘤、抗菌等多种药理作用;通过酸解法辅助超声波、表面活性剂、响应曲面法等优化提高提取效率,兼有溶剂法、氧化法、生物酶法提取法;采用碱溶酸沉法、高效逆流色谱、大孔树脂吸附技术进一步分离与纯化得到生产原料;采用纳米技术研制纳米载体制剂,提高其在体内的生物利用度和延长作用时间,并对制剂的处方及工艺进行分析。以期为其扩大临床应用提供依据。
Abstract：Ellagic acid, which exists widely in a variety of plants, is one of the major biological active substances,and it is a great practical significance to research about its pharmacological action, extraction, isolation, purification and preparation. By reviewing the literatures at home and abroad in recent years, the research showed that ellagic acid had antioxidant, anti-tumor, antibacterial and other pharmacological effects; Extracted by acid hydrolysis assisting ultrasonic, surface active agent, or response surface method for optimizing the extraction efficiency,also contained the solvent method, oxidation method, and biological enzyme method; Separated and purificated for production materials by alkali soluble acid precipitation method, high performance counter current chromatography,or macroporous resin adsorption technology; Developed nano preparation by nano carrier technology for improving the bioavailability and prolonging the action time of the ellagic acid in vivo, with analyzing formulation and preparation process. The article can provide a literature basis for the expansion of clinical applications of ellagic acid.
Abuelsaad A.S.A.,Mohamed I.,Allam G.,and Al-Solumani A.A.,2013,Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model,Life Sciences,93(20):714-722
Aiyer H.S.,and Gupta R.C.,2010,Berries and ellagic acid prevent estrogeninduced mammary tumorigenesis by modulating enzymes of estrogen metabolism,Cancer Prevention Research,3(6):727-737
AL-Kharusin N.,Babiker H.A.,AL-Salam S.,Waly M.I.,Nemmar A.,AL-Lawati I.,Yasin J.,Beegam S.,and Ali B.H.,2013,Ellagic acid protects against cisplatin-induced nephrotoxicity in rats:a dose-dependent study,European Review for Medical and Pharmacological Sciences,17(3):299-310
Avachat A.M.,and Patel V.G.,2014,Self nanoemulsifying drug delivery system of stabilized ellagic acid-phospholipid complex with improved dissolution and permeability,Saudi Pharmaceutical Journal,23(3):276-289
Colombo E.,Sangiovanni E.,and Dell'Agli M.,2013,A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract,Evidence-Based Comple mentary and Alternative Medicine,2013:1-16
Edderkaoui M.,Lugea A.,Hui H.X.,Eibl G.,Lu Q.Y.,Moro A.,Lu X.Y.,Li G.,Go V.L.,and Pandol S.J.,2013,Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma,cancer,and Stellate cells,Nutrition and Cancer,65(8):1232-1244
Edderkaoui M.,Odinokova I.,Ohno I.,Gukovsky I.,Go V.L.W.,Pandol S.J.,and Gukovskaya A.S.,2008,Ellagic acid induces apoptosis through inhibition of nuclear factor K B in pancreatic cancer cells,World Journal of Gastroenterology,14(23):3672-3680
Fan G.F.,Tong X.H.,Dong S.Y.,Jiang G.J.,and Tao L.,2014,The effect of ellagic acid on the function of gap junction of Hela cells with stable expression of Cx32,Bengbu Yixueyuan Xuebao(Journal of Bengbu Medical College),39(5):564-567(范高福,童旭辉,董淑英,蒋国君,陶亮,2014,鞣花酸对转染并稳定表达Cx32的He La细胞缝隙连接功能的影响,蚌埠医学院学报,39(5):564-567)
Girdhani S.,Bhosle S.M.,Thulsidas S.A.,Kumar A.,and Mishra K.P.,2005,Potential of radiosensitizing agents in cancer chemo-radiotherapy,Journal of Cancer Research and Therapeutics,1(3):129-131
Gong K.,Zhan X.L.,Guo Z.T.,Xue J.P.,Li J.B.,and Sheng W.,2014,Study on extraction of total flavonoids from pomegranate leaf by surfactant,Shipin Gongye Keji(Science and Technology of Food Industry),35(23):261-265(宫坤,詹小龙,郭中婷,薛建平,李进步,盛玮,2014,表面活性剂辅助提取石榴叶中总黄酮工艺的研究,食品工业科技,35(23):261-265)
Gonzalez-Sarrías A.,Larrosa M.,Toma觃s-Barbera觃n F.A.,Dolara P.,and Espín J.C.,2010,NF-κB-dependent anti-inflammtory activity of urolithins,gut microbiota ellagic acid-derived metabolites,in human colonic fibroblasts,British Journal of Nutrition,104(4):503-512
Han D.H.,Lee M.J.,and Kim J.H.,2006,Antioxidant and apoptosis-inducing activities of ellagic acid,Anticancer Research,26(5):3601-3606
Hseu Y.C.,Chou C.W.,Senthil Kumara K.J.,Fug K.T.,Wang H.M.,Hsu L.S.,Kuo Y.H.,Wu C.R.,Chen S.C.,and Yang H.L.,2012,Ellagic acid protects human keratinocyte(Ha Ca T)cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes,Food Chemical Toxicology,50(5):1245-1255
Hussein M.Z.,Al-Ali S.H.,Zainal Z.,and Hakim M.N.,2011,Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent,International Journal of Nanomedicine,6(1):1373-1383
Li W.F.,Ou Q.,Zhang D.F.,Zhang H.,and Zhao Z.B.,2013,Effect of ellagic acid on proliferation and SDF1α/CXCR4 signal path in breast cancer cells MDA-MB-231,Zhonghua Ruxianbing Zazhi(Chinese Journal Breast Disease(Electronic Edition)),7(6):415-418(李文仿,欧琴,张丹峰,张华,赵宗彬,2013,鞣花酸对乳腺癌细胞MDA-MB-231增殖及SDF1α/CXCR4信号通路的影响,中华乳腺病杂志(电子版),7(6):415-418)
Li X.P.,Liang Q.,Xin X.L.,and Wang Y.H.,2010,Study on the antioxidation activity of extraction of ellagic acid from red raspberry,Shipin Keji(Food Science and Technology),35(5):182-185(李小萍,梁琪,辛秀兰,王彦辉,2010,红树莓果中鞣花酸提取物的抗氧化性研究,食品科技,35(5):182-185)
Li X.P.,Xin X.L.,Liu Y.H.,and Liang Q.,2010,Study on the extraction processing of ellagic acid form the fruit of red raspberry,Shipingongye Keji(Science and Technology of Food Industry),31(1):277-279(李小萍,辛秀兰,刘亚红,梁琪,2010,红树莓果实中鞣花酸的提取工艺研究,食品工业科技,31(1):277-279)
Liu R.,Li J.K.,Cheng Y.J.,Wang L.F.,Huo T.B.,and Xue J.Y.,2015,Effect of pomegranate ellagic acid(PEA)on the expression of lipogenesis and lipolysis genes in hyperlipidemic hamsters,Yingyang Xuebao(Acta Nutrimenta Sinica),37(4):399-403(刘润,李建科,程玉江,王丽芳,霍天博,薛佳宜,2015,石榴鞣花酸对高脂血仓鼠肝脏脂质合成与分解基因表达的影响,营养学报,37(4):399-403)
Lo H.H.,Hsieh S.E.,Tsai K.J.,and Chung J.G.,1999,The effects of ellagic acid on arylamine N-acetyltransferase activity in the bacterium Pseudomonas aeruginosa,Drug and Chemical Toxicology,22(3):555-562
Marín M.,Giner R.M.,Ríos J.L.,and Recio M.C.,2013,Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis,Journal of Ethnopharmacology,150(3):925-934
Pitchakarn P.,Chewonarin T.,Ogawa K.,Suzuki S.,Asamoto M.,Takahashi S.,Shirai T.,and Limtrakul P.,2013,Ellagic Acid inhibits migration and invasion by prostate cancer cell lines,Asian Pacific Journal of Cancer Prevention,14(5):2859-2863
Qin R.X.,and Zhou H.,2014,Advances in research of antibacterial sensitizers from natural products,Zhongguo Xinyao Zazhi(Chinese Journal of New Drugs),23(11):1285-1289(覃容欣,周红,2014,植物来源抗菌增敏剂的研究进展,中国新药杂志,23(11):1285-1289)
Sharma G.,Italia J.L.,Sonaje K.,Tikooc K.,and Ravi Kumar M.N.V.,2007,Biodegradable in situ gelling system for subcutaneous administration of ellagic acid and ellagic acid loaded nanoparticles:evaluation of their antioxidant potential against cyclosporine induced nephrotoxicity in rats,Journal of Control Release,118(1):27-37
Shen D.C.,2013,Study on manufacturing technology of ellagic acid from the wastes of processing tannin acid in Chinese gall,Thesis for M.S.,Hunan Agricultural University,Supervisor:Xiao W.J.,pp.38-50(盛达成,2013,利用五倍子单宁酸生产废弃物制备鞣花酸研究,硕士学位论文,湖南农业大学,导师:肖文军,pp.38-50)
Sohn E.H.,Koo H.J.,Hang D.T.T.,Jang S.A.,Namkoong S.,Lim J.D.,and Kang S.C.,2013,Protective effects of ellagic acid on ethanol-induced toxicity in hepatic Hep G2 cells,Molecular and Cellular Toxicology,9(3):249-256
Sonaje K.,Italia J.L.,Sharma G.,Bhardwaj V.,Tikoo K.,and Ravi Kumar M.N.V.,2007,Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats,Pharmaceutical Research,24(5):899-908
Spencer W.A.,Jeyabalan J.,Kichambre S.,and Gupta R.C.,2011,Oxidatively generated DNA damage following Cu(Ⅱ)-Catalysis of dopamine and related catecholamine neurotransmitters and neurotoxins:role of reactive oxygen species,Free Radical Biology and Medicine,50(1):139-147
Takuo K.,Ishida H.,Yokota M.,and Yoshida M.,1984,Studies on antihemorrhagic substances in Herbs classified as hemostatics in Chinese medicineⅢon the antihemorrhagic principle in Sanguisorba officinallis L,Chemical and Pharmaceutical Bulletin,32(11):4478-4481
Wang L.,Ho J.,Glackin C.,and Martins-Green M.,2012,Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis,Translational Oncology,5(5):344-355
Wang N.,Wang Z.Y.,Mo S.L.,Loo T.Y.,Wang D.M.,Luo H.B.,Yang D.P.,Chen Y.L.,Shen J.G.,and Chen J.P.,2012,Ellagic acid,a phenolic compound,exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer,Breast Cancer Research and Treatment,134(3):943-955
Wang Z.J.,Wang G.Y.,Shi G.F.,Chen F.W.,and Yao R.X.,2014,Optimization of acidification process conditions for preparing ellagic acid from pomegranate peel by response surface methodology,Shipin Gongye Keji(Science and Technology of Food Industry),35(7):246-250(王振菊,王国英,史高峰,陈富文,姚瑞星,2014,响应面法优化从石榴皮制备鞣花酸的工艺研究,食品工业科技,35(7):246-250)
Whitley A.C.,Stoner G.D.,Darby M.V.,and Walle T.,2003,Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid extensive binding to protein and DNA,Biochemical Pharmacology,66(6):907-915
Wu X.F.,2008,Ellagic acid production using pomegranate husk and leaves as raw materials,Thesis for M.S.,Beijing University of Technology,Supervisor:Yuan Q.P.,pp.34-45(吴兴付,2008,以石榴皮,石榴叶为原料制备鞣花酸,硕士学位论文,北京化工大学,导师:袁其朋,pp.34-45)
Xin X.L.,Zhang D.S.,Chen L.,Wang W.B.,and Zhang M.L.,2011,Isolation and purification of ellagic acid from raspberry by high-speed counter-current chromatography,Shipin Yanjiu Yu Kaifa(Food Research and Development),32(8):65-67(辛秀兰,张东升,陈亮,王维彬,张明隆,2011,高速逆流色谱分离纯化红树莓果中的鞣花酸,食品研究与开发,32(8):65-67)
Xing X.P.,Yang X.X.,Lu J.,and Cao Y.H.,2015,Studies on the anti-aging effect of ellagic acid from pomegranate and its mechanism of action,Shipin Yu Shengwujishu Xuebao(Journal of Food Science and Biotechnology),34(4):436-442(邢晓平,杨笑笑,卢婕,曹玉华,2015,石榴皮中鞣花酸的抗衰老性能及机理研究,食品与生物技术学报,34(4):436-442)
Xu Z.G.,Cai Y.H.,Fan G.F.,and Yuan X.,2015,Application progress of Bacillus natto and its development prospective,Jiyinzuxue Yu Yingyong Shengwuxue(Genomics and Applied Biology),34(11):2532-2537(胥振国,蔡玉华,范高福,袁星,2015,纳豆芽孢杆菌应用研究进展及开发前景,基因组学与应用生物学,34(11):2532-2537)
Xue M.Y.,Luo X.Y.,Zhan Z.H.,and Chen Q.B.,2012,The anti-allergy effect of ellagic acid from Rubuso suavissimus S.Lee,Shipinyanjiu Yu Kaifa(Food Research and Development),33(11):208-211(薛茗月,罗星晔,湛志华,陈全斌,2012,甜茶中鞣花酸抗过敏性实验研究,食品研究与开发,33(11):208-211)
Yang X.X.,Xing X.P.,Ji B.H.,Lu J.,and Cao Y.H.,2013,Study on preparation of ellagic acid by hydrolysis from pomegranate peel,Shipingongye Keji(Science and Technology of Food Industry),34(12):284-288(杨笑笑,邢晓平,纪白慧,卢婕,曹玉华,2013,水解法制备石榴皮鞣花酸工艺研究,食品工业科技,34(12):284-288)
Zhang H.,Pei G.Z.,Li G.H.,Sun Li.,and Chen W.,2012,Preparation and content determination of ellagic acid tablet,Zhongguo Shiyan Fangjixue Zazhi(Chinese Journal of Experimental Traditional Medical Formulae),18(13):39-42(张华,裴桂珍,李桂华,孙丽,陈文,2012,鞣花酸片剂的制备及其含量测定,中国实验方剂学杂志,18(13):39-42)
Zoe Draelos M.D.,Amanda Dah B.S.,Margarita Yatskayer M.S.,Chen N.,Yevgeniy Krol B.S.,and Christian O.,2013,Dyspigmentation,skin physiology,and a novel approach to skin lightening,Journal of Cosmetic Dermatology,12(4):247-253
基本信息:
DOI：10.13417/j.gab.035.003562
中图分类号:R285;R283
引用信息:
[1]范高福,胥振国,刘修树,等.植物提取物鞣花酸的药理作用及制剂研究进展[J].基因组学与应用生物学,2016,35(12):3562-3568.DOI:10.13417/j.gab.035.003562.
基金信息:
安徽省高校自然基金研究重点项目(KJ2015A440);安徽省高校自然基金研究重点项目(KJ2015A406);安徽省高校自然基金研究重点项目(KJ2016A616);安徽省高校自然基金研究重点项目(KJ2016A613)共同资助;; 安徽省教育厅重点质量工程项目“药学示范实验实训中心”(2014sxzx047)
2017-03-20
2017-03-20
2017-03-20