基因组学与应用生物学

参考文献

Adamson I.Y.,and Bowden D.H.,1979,Bleomycin-induced in-jury and metaplasia of alveolar type2cells,relationship ofcellular responses to drug presence in the lung,Am.J.Pathol.,96(2):531-544

Adamson I.Y.,1976,Pulmonary toxicity of bleomycin,Environ.Health Perspect,16:119-125

Aso Y.,Yoneda K.,and Kikkawa Y.,1976,Morphologic andbiochemical study of pulmonary changes induced bybleomycin in mice,Lab Invest.,35(6):558-568

Barker N.,van Es J.H.,Kuipers J.,Kujala P.,van den Born M.,Cozijnsen M.,Haegebarth A.,Korving J.,Begthel H.,PetersP.J.,and Clevers H.,2007,Identification of stem cells insmall intestine and colon by marker geneLgr5,Nature,449:1003-1007

Barth P.J.,Muller B.,Wagner U.,and Bittinger A.,1995,Quanti-tative analysis of parenchymal and vascularalterations inNO2-induced lung injury in rats,Eur.Respir.J.,8(7):1115-1121

Bertoncello I.,and McQualter J.L.,2010,Endogenous lungstemcells:What is their potential for use in regenerativemedicine?Expert Rev.Respir.Med.,4(3):349-362

Borthwick D.W.,Shahbazian M.,Krantz Q.T.,Dorin J.R.,andRandell S.H.,2001,Evidence for stem-cell niches in the tra-cheal epithelium,Am.J.Respir.Cell Mol.Biol.,24(6):662-670

Buckpitt A.,Chang A.M.,Weir A.,van Winkle L.,Duan X.,Philpot R.,and Plopper C.,1995,Relationship of cy-tochrome P450activity to Clara cell cytotoxicity.IV.metabolism of naphthalene and naphthalene oxide in mi-crodissected airways from mice,rats,and hamsters,Mol.Pharmacol.,47(1):74-81

Chapman H.A.,Li X.,Alexander J.P.,Brumwell A.,Lorizio W.,Tan K.,Sonnenberg A.,Wei Y.,and Vu T.H.,2011,Integrinα6β4identifies an adult distal lung epithelial populationwith regenerative potential in mice,J.Clin.Invest.,121(7):2855-2862

Clayton E.,Doupe D.P.,Klein A.M.,Winton D.J.,Simons B.D.,and Jones P.H.,2007,A single type of progenitor cell main-tains normal epidermis,Nature,446:185-189

Derks C.M.,and De Francquen P.,1980,Distribution of ventila-tion-perfusion ratios in pneumonectomized dogs,Respiration,39(2):61-74

Ding B.S.,Nolan D.J.,Guo P.,Babazadeh A.O.,Cao Z.,Rosen-waks Z.,Crystal R.G.,Simons M.,Sato T.N.,Worgall S.,Shido K.,Rabbany S.Y.,and Rafii S.,2011,Endothelial-de-rived angiocrine signals induce and sustain regenerativelung alveolarization,Cell,147(3):539-553|

Dor Y.,Brown J.,Martinez O.I.,and Melton D.A.,2004,Adult-pancreaticβ-cells are formed by self-duplication rather thanstem-cell differentiation,Nature,429:41-46

Evans M.J.,Cabral L.J.,Stephens R.J.,and Freeman G.,1975,Transformation of alveolar type2cells to type1cells fol-lowing exposure to NO2,Exp.Mol.Pathol.,22(1):142-150

Hong K.U.,Reynolds S.D.,Watkins S.,Fuchs E.,and Stripp B.R.,2004,In vivodifferentiation potential of tracheal basal cells:Evidence for multipotent and unipotent subpopulations,Lung Cell Mol.Physiol.,286(4):L643-L649

Kim C.F.,Jackson E.L.,Woolfenden A.E.,Lawrence S.,Babar I.,Vogel S.,Crowley D.,Bronson R.T.,and Jacks T.,2005,I-dentification of bronchioalveolar stem cells in normal lungand lung cancer,Cell,121(6):823-835

Kumar P.A.,Hu Y.Y.,Yamamoto Y.,Hoe N.B.,Wei T.S.,MuD.,Sun Y.,Joo L.S.,Dagher R.,Zielonka E.M.,Wang D.Y.,Lim B.,Chow V.T.,Crum C.P.,Xian W.,and McKeon F.,2011,Distal airway stem cells yield alveoliin vitroand dur-ing lung regeneration following H1N1influenza infection,Cell,147(3):525-538

Li L.,Wei Y.,van Winkle L.,Zhang Q.Y.,Zhou X.,Hu J.P.,Xie F.,Kluetzman K.,and Ding X.X.,2011,Generation and charac-terization of aCyp2f2-null mouse and studies on the role ofCYP2F2innaphthalene-inducedtoxicityinthelungandnasalolfactorymucosa,J.Pharmacol.Exp.Ther.,339(1):62-71

McQualter J.L.,Yuen K.,Williams B.,and Bertoncello I.,2010,Evidence of an epithelial stem/progenitor cell hierarchy inthe adult mouse lung,PNAS,107(4):1414-1419

Narasaraju T.,Yang E.,Samy R.P.,Ng H.H.,Poh W.P.,Liew A.A.,Phoon M.C.,van Rooijen N.,and Chow V.T.,2011,Ex-cessive neutrophils and neutrophil extracellular traps con-tribute to acute lung injury of influenza pneumonitis,Am.J.Pathol.,179(1):199-210

Pagano A.,and Barazzone-Argiroffo C.,2003,Alveolar celldeath in hyperoxia-induced lung injury,Annals of the NewYork Academy of Sciences,1010:405-416

Rannels D.E.,and Rannels S.R.,1988,Compensatory growth ofthe lung following partial pneumonectomy,Exp.Lung Res.,14(2):157-182

Rawlins E.L.,and Hogan B.L.,2006,Epithelial stem cells of thelung:privileged few or opportunities for many?Develop-ment,133:2455-2465

Rawlins E.L.,Okubo T.,Xue Y.,Brass D.M.,Auten R.L.,Hasegawa H.,Wang F.,and Hogan B.L.,2009,The role ofScgb1a1+Clara cells in the long-term maintenance and re-pair of lung airway,but not alveolar epithelium,Cell StemCell,4(6):525-534

Reynolds S.D.,Hong K.U.,Giangreco A.,Mango G.W.,GuronC.,Morimoto Y.,and Stripp B.R.,2000,Conditional Claracell ablation reveals a self-renewing progenitor function ofpulmonary neuroendocrine cells,Am.J.Physiol.Lung CellMol.Physiol.,278(6):L1256-L1263

Rock J.R.,Barkauskas C.E.,Cronce M.J.,Xue Y.,Harris J.R.,Liang J.,Noble P.W.,and Hogan B.L.M.,2011,Multiplestromal populations contribute to pulmonary fibrosis with-out evidence for epithelial to mesenchymal transition,PNAS,108(52):E1475-E1483

Rosler E.S.,Brandt J.E.,Chute J.,and Hoffman R.,2000,Aninvivocompetitive repopulation assay for various sources ofhuman hematopoietic stem cells,Blood,96(10):3414-3421

Shackleton M.,Vaillant F.,Simpson K.J.,Stingl J.,Smyth G.K.,Asselin-Labat M.L.,Wu L.,Lindeman G.J.,and Visvader J.E.,2006,Generation of a functional mammary gland from asingle stem cell,Nature,439:84-88

Stingl J.,Eirew P.,Ricketson I.,Shackleton M.,Vaillant F.,Choi D.,Li H.I.,and Eaves C.J.,2006,Purification and uniqueproperties of mammary epithelial stem cells,Nature,439:993-997

Suzuki M.,Machida M.,Adachi K.,Otabe K.,Sugimoto T.,Hayashi M.,and Awazu S.,2000,Histopathological study ofthe effects of a single intratracheal instillation of surface ac-tive agents on lung in rats,J.Toxicol.Sci.,25:49-55

Wang J.,Wang S.,Manzer R.,McConville G.,and Mason R.J.,2006,Ozone induces oxidative stress in ratalveolar typeⅡand typeⅠ-like cells,Free Radic.Biol.Med.,40(11):1914-1928

Xu X.,D'Hoker J.,StangéG.,BonnéS.,De Leu N.,Xiao X.,Van de Casteele M.,Mellitzer G.,Ling Z.,Pipeleers D.,Bouwens L.,Scharfmann R.,Gradwohl G.,and HeimbergH.,2008,βcells can be generated from endogenous progen-itors in injured adult mouse pancreas,Cell,132(2):197-207

Zacharek S.J.,Fillmore C.M.,Lau A.N.,Gludish D.W.,Chou A.,Ho J.W.,Zamponi R.,Gazit R.,Bock C.,Jger N.,Smith Z.D.,Kim T.M.,Saunders A.H.,Wong J.,Lee J.H.,Roach R.R.,Rossi D.J.,Meissner A.,Gimelbrant A.A.,Park P.J.,andKim C.F.,2011,Lung stem cell self-renewal relies onBMI1-dependent control of expression at imprinted loci,Cell Stem Cell,9(3):272-281