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通过进行系统回顾和分析,研究牙周炎治疗对改善动脉粥样硬化特征的稳定性。在Medline-PubMed、Cochrane CENTRAL和EMBASE中检索文献,基于牙周控制的干预实验(包括一个非干预组),来提取数据并进行荟萃分析。荟萃分析显示了hsCRP (-0.50 mg/L, 95%CI:-0.78;-0.22)、IL-6 (-0.48 ng/L, 95%CI:-0.90;-0.06)、TNF-α(-0.75 pg/mL, 95%CI:-1.34,-0.17)、纤维蛋白原(-0.47 g/L, 95%CI:-0.76;-0.17)、总胆固醇(-0.11 mmol/L, 95%CI:-0.21;-0.01)和有利于牙周干预的HDL-C (0.04 mmol/L, 95%CI:0.03; 0.06)之间的显著加权平均差异(WMD)。重要的是,伴有并发症的牙周炎患者大多从牙周治疗中获益;对于hsCRP(-0.71 mg/L, 95%CI:-1.05;-0.36)、IL-6 (-0.87 ng/L, 95%CI:-0.97;-0.78)、甘油三酯(-0.24 mmol/L, 95%CI:-0.26;-0.22)、总胆固醇(-0.15 mmol/L, 95%CI:-0.29;-0.01)、HDL-C (0.05 mmol/L, 95%CI; 0.03; 0.06)和Hb A1c (-0.43%, 95%CI:-0.60;-0.25)的水平观察到了显著的加权平均差异。牙周治疗可改善内皮功能,减少动脉粥样硬化性疾病的生物标志物,对那些已经患有心血管疾病和/或糖尿病的人更为显著。
Abstract：To study the stability of periodontitis treatment to improve the characteristics of atherosclerosis by systematic retrospect and meta analysis. Based on the intervention trial of periodontal control(including a non-intervention trial), searching literature in Medline-Pub Med, Cochrane CENTRAL and EMBASE database. Then extracting relevant data in database and conducting meta-analysis. A significantly weighted average difference between hsCRP(-0.50 mg/L, 95% CI:-0.78;-0.22), IL-6(-0.48 ng/L, 95% CI:-0.90;-0.06), TNF-α(-0.75 pg/mL, 95%CI:-1.34;-0.17), fibrinogen(-0.47 g/L, 95% CI:-0.76;-0.17), total cholesterol(-0.11 mmol/L, 95% CI:-0.21;-0.01) and benefit to periodontal intervention of HDL-C(0.04 mmol/L, 95% CI: 0.03; 0.06). Importantly, most periodontitis patients with complication benefit from periodontal treatment; A significantly weighted average difference between hs CRP(-0.71 mg/L, 95% CI:-1.05;-0.36), IL-6(-0.87 ng/L, 95% CI:-0.97;-0.78), triglyceride(-0.24 mmol/L, 95% CI:-0.26;-0.22), total cholesterol(-0.15 mmol/L, 95% CI:-0.29;-0.01), HDL-C(0.05 mmol/L,95%CI; 0.03; 0.06) and HbA1c(-0.43%, 95% CI:-0.60;-0.25) level was observed. Conclusion: Periodontitis treatment can improve endothelial function and reduce biomarkers of atherosclerosis disease. These functions are more significantly for those who already have cardiovascular disease and/or diabetes.
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基本信息:
DOI：10.13417/j.gab.039.001925
中图分类号:R781.42;R543.5
引用信息:
[1]朱娟,王苏平,刘艳,等.牙周炎的治疗对动脉粥样硬化特征的改善分析[J].基因组学与应用生物学,2020,39(04):1925-1930.DOI:10.13417/j.gab.039.001925.
2020-04-25
2020-04-25