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为探讨雾化吸入布地奈德对鼻咽癌调强放疗致鼻口等相关并发症的防治作用,用随机数字法将行调强放疗治疗的80例鼻咽癌患者分为观察组与对照组,各40例,观察组放疗期间给予布地奈德雾化吸入干预,对照组常规生理盐水干预,比较两组放疗前后气导听阈变化、放疗后鼻咽粘膜反应程度、不同放射剂量III度黏膜损伤情况及相关并发症发生率。观察组放疗结束后语言频区平均气导听阈值显著低于对照组(p<0.05);观察组放疗结束后鼻咽黏膜反应程度显著轻于对照组(p<0.05);观察组放疗剂量31~50 Gy、51~70 Gy时3度黏膜损伤发生率均显著低于对照组(p<0.05);观察组中耳炎、副鼻窦炎、鼻腔粘连、后鼻孔狭窄及咽喉干燥感发生率分别为27.50%、57.50%、15.00%、10.00%、22.50%,均显著低于对照组的50.00%、87.50%、37.50%、30.00%、75.00%,差异有统计学意义(p<0.05)。鼻咽癌调强放疗治疗期间给予布地奈德雾化吸入干预能明显减轻患者鼻咽黏膜损伤程度,有效减少鼻咽口相关并发症发生。
Abstract：In o rder to investigate the preventive and therapeutic effect of budesonide atomization inhalation on nose and mouth related complications which were induced by intensity-modulated radiotherapy of nasopharyngeal carcinoma, eighty patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy were randomized into the observation group and the control group, 40 cases in each group. The observation group was given budesonide atomization inhalation intervention during radiotherapy while the control group was given normal saline intervention. The changes of air conduction thresholds before and after radiotherapy, degree of nasopharyngeal mucosa reactions after radiotherapy, grade Ⅲ mucosal injury of different radiation doses and incidence of related complications were compared between the two groups. In observation group, the average air conduction hearing threshold in the speech frequency area after radiotherapy was significantly lower than that in the control group(p<0.05); and the degree of nasopharyngeal mucosa reactions after radiotherapy was significantly milder than that in the control group(p<0.05); When the radiation doses were 31 to 50 Gy and 51 to 70 Gy, the incidence rate of grade Ⅲ mu cosal injury in the observation group were significantly lower than those in the control group(p<0.05); The incidence rate of otitis media, paranasal sinusitis, nasal adhesion, choanal stenosis and dry thr oat in observation group were 27.50%, 57.50%, 15.00%, 10.00%, and 22.5%, respectively, which were significantly lower than those in the control group(50.00%, 87.50%, 37.50%, 30.00%, 75.00%), and the differences were statistically significant( p < 0. 05). The research showed that the application of budesonide atomization inhalation during intensity modulated radiotherapy for nasopharyngeal carcinoma could significantly reduce the degree of nasopharyngeal mucosa injury and the incidence of nasopharynx and mouth related complications.
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基本信息:
DOI：10.13417/j.gab.036.002308
中图分类号:R739.63
引用信息:
[1]杨黎,邓嘉虹,仼钢,等.雾化吸入布地奈德可降低鼻咽癌调强放疗致鼻口等相关并发症发生率[J].基因组学与应用生物学,2017,36(06):2308-2312.DOI:10.13417/j.gab.036.002308.
基金信息:
云南省厅级项目(2010W-11-3-007-03)资助
2017-06-25
2017-06-25