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探讨腹腔镜手术治疗宫颈癌的临床效果及对生存质量的影响。选取2010年2月至2012年3月在我院治疗的宫颈癌患者125例,根据患者最终选取的治疗方式分为观察组(n=68)和对照组(n=57),观察组给予腹腔镜手术,对照组给予开腹手术,观察两组手术时间、淋巴结切除数目、术中出血量等,检测两组手术前后肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)和IL-6水平;随访患者术后5年生存情况和癌症治疗功能总体评价量表(FACT-G)评分。结果显示,观察组手术时间和淋巴结清除数目分别为(224.19±45.28)min和(24.59±3.01)枚,明显多于对照组(p<0.05),而术中出血量、排气时间和住院时间分别为(301.02±40.47)m L、(2.19±0.50)d和(17.01±5.11)d,明显少于对照组(p<0.05);观察组术后1 d IFN-γ、TNF-α和IL-6分别为(40.01±9.91)pg/m L、(17.30±6.43)pg/m L和(14.01±4.22)pg/m L,明显低于对照组(p<0.05);两组手术前后IL-4比较差异无统计学意义(p>0.05);观察组术后1年、3年和5年总生存率分别为91.94%、87.10%和80.65%,与对照组比较差异无统计学意义(p>0.05);观察组术后1年、3年和5年FACT-G评分分别为(65.37±10.03)分、(75.28±12.13)分和(84.46±12.01)分,明显高于对照组(p<0.05)。腹腔镜手术在宫颈癌治疗中有较好的应用价值,对患者全身免疫系统干扰小,患者术后生存质量好。
Abstract：To investigate the clinical effect of l aparoscopic surgery on cervical cancer and its influence on the quality of life,125 patients with cervical cancer treated in our hospital from February 2010 to March 2012 were selected.The patients were divided into observation group(n=68)and control group(n=57)according to the final treatment.The observation group received laparoscopic surgery,while the control group received laparotomy.The operation time,the number of resected lymph nodes and the amount of bleeding during operation and so on were observed in the two groups.Levels of tumor necrosis factor-α(TNF-α),interferon(IFN-γ),interleukin-4(IL-4)and IL-6 in the two groups before and after the surgery were detected.The survival conditions 5 years after the surgery and functional assessment of cancer therapy-general(FACT-G)score were followed up.The results showed that,the operation time and the number of dissected lymph nodes of the observation group were(224.19±45.28)min and(24.59±3.01)min pieces respectively,which were significantly higher than the control group(p<0.05).The amount of bleeding,exhaust time and hospitalization time were(301.02±40.47)m L,(2.19±0.50)d and(17.01±5.11)d,respectively,which were remarkably less than the control group(p<0.05);IFN-γ,TNF-α,and IL-6 in the observation group 1 d after the surgery were(40.01±9.91)pg/m L,(17.30±6.43)pg/m L and(14.01±4.22)pg/m L respectively,which were markedly lower than the control group(p<0.05);there was no significant difference of IL-4 between the two groups before and after the operation(p>0.05);The overall survival rates of the observation group 1,3 and 5 years after the surgery were 91.94%,87.10%and 80.65%,respectively,and compared with the control group,the difference was not statistically significant(p>0.05);The FACT-G scores of the observation group 1,3 and 5 years after the surgery were(65.37±10.03)points,(75.28±12.13)points and(84.46±12.01)points,respectively,which were evidently higher than that of the control group(p<0.05).This study suggested that,laparoscopic surgery might have better application value in the treatment of cervical cancer.It might have little interference to the patients'systemic immune system and the quality of their life after the surgery would be good.
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基本信息:
DOI：10.13417/j.gab.037.000596
中图分类号:R737.33
引用信息:
[1]刘大纯,王晓霜.腹腔镜手术治疗宫颈癌的临床效果及对生存质量的影响[J].基因组学与应用生物学,2018,37(02):596-603.DOI:10.13417/j.gab.037.000596.
基金信息:
重庆市中医院资助
2018-02-25
2018-02-25