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溶解性多糖单加氧酶(lytic polysaccharide monooxygenases, LPMOs)是近些年才发现的一种蛋白,能够催化多糖葡萄糖苷键的氧化裂解,显著促进丝状真菌纤维素酶系对木质纤维素的降解作用。本综述对溶解性多糖单加氧酶发现过程、晶体结构、反应机制、活性位点和区域选择性、与纤维素酶的协同作用等方面分别进行了阐述,并对溶解性多糖单加氧酶对于木质纤维素降解方面的应用进行了论述。
Abstract：Lytic polysaccharide monooxygenases(LPMOs) is a protein found in recent years, which can catalyze the oxidative cleavage of polysaccharide glucoside bonds, and significantly promote the degradation of lignocellulose by cellulase system of filamentous fungi. In this study, the discovery progress, crystal structure,reaction mechanism, active site and regioselectivity of LPMOs and its synergistic effect with cellulase were described, respectively. The application of LPMOs in lignocellulose degradation was also discussed.
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基本信息:
DOI：10.13417/j.gab.037.005339
中图分类号:Q936
引用信息:
[1]白雪,张梦娣,张东远,等.丝状真菌溶解性多糖单加氧酶的研究进展[J].基因组学与应用生物学,2018,37(12):5339-5348.DOI:10.13417/j.gab.037.005339.
基金信息:
国际科技合作专项(1504WKCA028);; 甘肃省科技支撑计划项目(1304NKCA143);; 甘肃省高校科研项目(2013A-011)共同资助
2018-10-08
2018-10-08
2018-10-08