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新辅助化疗(NAGT)可以改善对化疗有反应的食道癌患者的预后,对无反应者无效,因而建立有效方法预测化疗效果意义重大。血液高凝状态与化学抗性相关,由癌细胞组织因子(TF)上调所致,本研究旨在探讨组织因子的表达与食道癌新辅助化疗反应的联系。在67名晚期食道癌患者中,对预处理活检标本的TF表达进行了免疫组化评估,并对临床病理因素和化疗反应进行分析,发现43.3%的肿瘤有TF表达,在所有临床病理参数中未观察到相关性。与TF阴性患者相比,TF阳性患者对化疗的临床和病理效果显著性更差。多变量分析发现TF表达与临床反应(p=0.043 1)以及无进展生存率(p=0.035 3)相关。结果表明,预处理活检标本中的TF表达级别可预测晚期食道癌的新辅助化疗效果。
Abstract：Neoadjuvant chemotherapy(NAGT) can improve the prognosis of esophageal cancer patients who respond to chemotherapy, but NAGT is ineffective in non-responders. Therefore, it is of great significance to establish an effective method to predict the effect of chemotherapy. Hypercoagulability of the blood is associated with chemical resistance. It is caused by upregulation of cancer tissue factor(TF). To explore the relationship between tissue factor expression and neoadjuvant chemotherapy in esophageal cancer. Immunohistochemical evaluation of TF expression in pretreated biopsy specimens was performed in 67 patients with advanced esophageal cancer.Clinical pathological factors and chemotherapeutic response were analyzed. TF expression was observed in 43.3%of tumors and no correlation was observed in all Clinical pathological parameters. Compared with TF-negative patients, TF-positive patients have worse significant correlation of clinical and pathological effects of chemotherapy. Multivariate analysis revealed that TF expression was associated with clinical response(p=0.043 1)and progression-free survival(p=0.035 3). The level of TF expression in pretreated biopsy specimens can predict the efficacy of neoadjuvant chemotherapy in advanced esophageal cancer.
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基本信息:
DOI：10.13417/j.gab.038.005795
中图分类号:R735.1
引用信息:
[1]暴玉振,亓永花,赵俊泉.基于组织因子预测食道癌化疗反应的实验研究[J].基因组学与应用生物学,2019,38(12):5795-5800.DOI:10.13417/j.gab.038.005795.
2019-12-25
2019-12-25