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T-box基因家族是一类重要的转录因子广泛存在于后生动物,该家族成员在脊椎动物胚胎发育和器官形成过程中发挥重要调控作用。目前,在金鱼(Carassius auratus var.)和鲤鱼(Cyprinus carpio)中还没有对T-box基因家族进行系统的研究。本研究利用金鱼和鲤鱼基因组数据,分别鉴定出分属5个亚家族的44和47个T-box基因家族成员。最后,比较了文昌鱼、哺乳动物(人和小鼠)和硬骨鱼类(斑马鱼,金鱼和鲤鱼)之间T-box基因家族成员数目的变化。结果显示文昌鱼T-box基因数目为11,少于哺乳动物的数目(17),约为斑马鱼数目(26)的一半,金鱼和鲤鱼T-box基因数目约为斑马鱼数目的二倍。硬骨鱼类特异的第3次全基因组复制(3R-WGD)和谱系特异(金鱼和鲤鱼祖先)的第4次全基因组复制(4R-WGD)显著增加了T-box基因家族成员的数目。本研究结果为金鱼和鲤鱼T-box基因家族的功能研究及性状改良提供了基础资料。
Abstract：The T-box gene family members are important transcription factors and play critical roles in embryonic development and organogenesis of vertebrate.At present,there is no systematic research on the T-box gene family in goldfish(Carassius auratus var.) and carp(Cyrinus carpio).The study identify 44 members of goldfish and 47 members of carp using the goldfish and carp genome database,respectively,and divided them into five subfamilies.Finally,we compared the number variation of T-box gene family members between amph-ioxus,mammals(human and mouse) and teleost fish(zebrafish,goldfish and common carp).The results showed that the number of T-box genes in amphioxus was 11,which was obvious less than that in mammals(17) and about half of the number in zebrafish(26).The number of T-box genes in goldfish and common carp was nearly twice that of zebrafish.We speculated that the effect of teleost-specific whole genome duplication(3 R-WGD) and lineage-specific whole genome duplication(4 R-WGD) on the number of T-box family genes in vertebrate.This study provides a theoretical basis for the function research of the goldfish and common carp T-box genes.
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基本信息:
DOI：10.13417/j.gab.039.004449
中图分类号:S917.4
引用信息:
[1]宋诗颖,崔文耀,甘武,等.金鱼和鲤鱼T-box基因家族成员鉴定及分析[J].基因组学与应用生物学,2020,39(10):4449-4456.DOI:10.13417/j.gab.039.004449.
基金信息:
上海市科委国际科技合作项目(15410723300)资助
2019-08-21
2019-08-21
2019-08-21