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普雷沃氏菌(Prevotella)是一类广泛存在于人类微生物群中的厌氧菌，近年来的研究显示其在女性生殖健康中的重要性。宫颈癌是全球范围内常见的一种恶性肿瘤，其发生与多种因素密切相关。近年来，研究逐渐揭示了阴道微生态失衡与人乳头瘤病毒(human papilloma virus,HPV)感染之间的复杂关系，普雷沃氏菌作为阴道微生物群的重要组成部分，在这一过程中发挥关键作用。本文系统综述了普雷沃氏菌在宫颈癌发生发展中的潜在作用，重点探讨了其丰度变化与HPV感染之间的相互作用。本文通过对现有研究的综合分析，揭示了普雷沃氏菌可通过调节宿主免疫反应和影响阴道微生态平衡等途径参与宫颈癌发病机制。这些发现不仅为理解普雷沃氏菌与宫颈癌的关联提供了新的理论视角，也为宫颈癌的早期预防、临床诊断和靶向治疗策略的开发提供了重要的科学依据。
Abstract：Prevotella is a type of anaerobic bacteria that is widely present in the human microbiome. Recent studies have highlighted its significance in female reproductive health. Cervical cancer remains a prevalent malignant tumor worldwide, with its development influenced by multiple factors. Recent studies have gradually uncovered the complex relationship between vaginal microecological imba-lance and human papilloma virus( HPV) infection. As a key component of the vaginal microbiota, Prevotella may play a critical role in this process. This review systematically summarizes the potential mechanisms of Prevotella in cervical carcinogenesis, with a focus on the interaction between its abundance dynamics and HPV infection. By synthesizing current evidence, we elucidate how Prevotella may contribute to the pathogenesis of cervical cancer by modulating host immune responses and disrupting vaginal microecological balance.These findings provide novel theoretical insights into the association between Prevotella and cervical cancer, while also offering a scientific foundation for early prevention, clinical diagnosis, and the development of targeted therapeutic strategies for cervical cancer.
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基本信息:
DOI：10.13417/j.gab.045.000016
中图分类号:R737.33;R711
引用信息:
[1]张贝,李晓乐,曹玉会,等.普雷沃氏菌与宫颈癌:阴道微生态与HPV感染的交互作用[J].基因组学与应用生物学,2026,45(01):16-24.DOI:10.13417/j.gab.045.000016.
基金信息:
国家自然科学基金项目(82160509); 甘肃省自然科学基金项目(20YF8FA046)共同资助
2025-12-18
2025-12-18
2025-12-18