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为探讨诺丽果对于长跑运动后氧化压力、组织伤害与分解反应的影响,本研究设计交叉试验,招募10名大学生运动员作为受试者,分为对照组和诺立组,其中诺立组每天饮用120 mL果汁共7 d,于最后一次饮用后1 d所有受试者均进行单次3 h的长跑运动,跑步距离为各受试者最佳马拉松速度的85%。在运动前、运动后立即、2 h后和12 h后分别抽血并分离血清进行生化分析,分析项目包含氧化压力(丙二醛,超氧岐化酶)、炎症(白介素6)、组织损伤(肌酸激酶,天门冬氨酸转氨酶,丙氨酸转氨酶)与分解合成指标(睾酮,皮质醇)。研究发现长跑运动后丙二醛、白介素6、肌酸激酶、皮质醇显著上升,而睾酮与睾酮/皮质醇比值(T/C值)显著降低。诺丽组的超氧岐化酶活性显著高于对照组。而诺丽组于运动后丙二醛浓度显著高于对照组,但白介素6、睾酮、睾酮/皮质醇比率显著低于对照组。本研究说明,虽然诺丽果可以提升抗氧化酶活性与降低运动后的炎症反应,但是应注意其增加运动后氧化伤害与降低合成反应的负面效果。
Abstract：To investigate the effects of noni fruit on oxidative stress, tissue damage and decomposition after long-distance running, 10 college athletes were recruited as subjects for the crossover study and be divided into control group and noni group. Subjects in noni group were asked to drink 120 m L of fruit juice daily for 7 d and on the day after the last drink, all subjects had a one-time 3-hour long run at 85% of the best marathon speed for each oneself. Blood samples were taken at point of before exercise, immediately after exercise, 2 h and 12 h after exercise, and biochemical analysis was performed to analyze the oxidative stress(malon dialdehyde, superoxide dismutase), inflammation(interleukin 6), tissue damage(creatine kinase, aspartate aminotransferase, alanine aminotransferase) and decomposition and synthesis index(testosterone, cortisol). The results showed that malon dialdehyde, interleukin 6, creatine kinase and cortisol significantly increased after long-distance running, while T/C ratio of testosterone and testosterone/cortisol significantly decreased. The superoxide dismutase activity in noni group was significantly higher than the control group. However, the concentration of malon dialdehyde in noni group was significantly higher than that in control group, but the ratio of testosterone, testosterone and testosterone/cortisol was significantly lower than that of control group. This study concluded that although noni fruit can enhance antioxidant enzyme activity and reduce inflammation after exercise, but should pay attention to its increased oxidative damage after exercise and reduce the negative effects of synthetic reactions.
Brancaccio P.,Maffulli N.,and Limongelli F.M.,2007,Creatine kinase monitoring in sport medicine,British Medical Bulletin,81(1):209-230
Chang Y.Y.,Lin Y.L.,Yang D.J.,Liu C.W.,Hsu C.L.,Tzang B.S.,and Chen Y.C.,2013,Hepatoprotection of noni juice against chronic alcohol consumption:Lipid homeostasis,antioxidation,alcohol clearance,and antiinflammation,Journal of Agricultural and Food Chemistry,61(46):11016-11024
Fischer C.P.,Hiscock N.J.,Penkowa M.,Basu S.,Vessby B.,Kallner A.,and Pedersen B.K.,2004,Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle,The Journal of Physiology,558(2):633-645
Gupta R.K.,and Patel A.K.,2013,Do the health claims made for Morinda citrifolia(noni)harmonize with current scientifc knowledge and evaluation of its biological effects,Asian Pacifc Journal of Cancer Prevention,14(8):4495-4499
Gupta R.K.,and Singh N.,2013,Morinda citrifolia(noni)alters oxidative stress marker and antioxidant activity in cervical cancer cell lines,Asi an Pacific Journal of Cancer Prevention,14(8):4603-4606
Hamada K.,Vannier E.,Sacheck J.M.,Witsell A.L.,and Roubenoff R.,2005,Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise,The FASEB Journal,19(2):264-266
Harada S.,Hamabe W.,Kamiya K.,Satake T.,Yamamoto J.,and Tokuyama S.,2009,Preventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemia,Biological and Pharmaceutical Bulletin,32(3):405-409
Huang H.L.,Ko C.H.,Yan Y.Y.,and Wang C.K.,2014,Antiad hesion and anti-inflammation effects of noni(Morinda citrifolia)fruit extracts on AGS cells during Helicobacter pylori infection,Journal of Agricultural and Food Chemistry,62(11):2374-2383
Karkoulias K.,Habeos I.,Charokopos N.,Tsiamita M.,Mazarakis A.,Pouli A.,and Spiropoulosa K.,2008,Hormonal responses to marathon running in non-elite athletes,European Journal of Internal Medicine,19(8):598-601
Kim H.J.,Lee Y.H.,and Kim C.K.,2007,Biomarkers of muscle and cartilage damage and inflammation during a 200 km run,European Journal of Applied Physiology,99(4):443-447
Kim Y.J.,Ahn J.K.,Shin K.A.,Kim C.H.,Lee Y.H.,and Park K.M.,2015,Correlation of cardiac markers and biomarkers with blood pressure of middle-aged marathon runners,The Journal of Clinical Hypertension,17(11):868-873
Kinoshita S.,Yano H.,and Tsuji E.,2003,An increase in damaged hepatocytes in rats after high intensity exercise,Acta Physiologica Scandinavica,178(3):225-230
Kupchak B.R.,Kraemer W.J.,Hoffman M.D.,Phinney S.D.,and Volek J.S.,2014,The impact of an ultramarathon on hormonal and biochemical parameters in men,Wilderness and Environmental Medicine,25(3):278-288
Landers-Ramos R.Q.,Jenkins N.T.,Spangenburg E.E.,Hagberg J.M.,and Prior S.J.,2014,Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men,European Journal of Applied Physiology,114(7):1377-1384
Lanier A.B.,2003,Use of nonsteroidal antiinflammatory drugs following exercise-induced muscle injury,Sports Medicine,33(3):177-186
Lippi G.,Schena F.,Montagnana M.,Salvagno G.L.,Banf G.,and Guidi G.C.,2011,Signifcant variation of traditional markers of liver injury after a half-marathon run,European Journal of Medicine,22(5):e36-e38
Lippi G.,Schena F.,Salvagno G.L.,Montagnana M.,Gelati M.,Tarperi C.,and Guidi G.C.,2008,Acute variation of biochemical markers of muscle damage following a 21-km,half-marathon run,Scandinavian Journal of Clinical and Laboratory Investigation,68(7):667-672
Ma D.L.,Chen M.,Su C.X.,and West B.J.,2013,In vivo antioxidant activity of deacetylasperulosidic acid in noni,Journal of Analytical Methods in Chemistry,2013(12):804504
Ma D.L.,West B.J.,Su C.X.,Gao J.H.,Liu T.Z.,and Liu Y.W.,2007,Evaluation of the ergogenic potential of noni juice,Phytotherapy Research,21(11):1100-1101
Min Y.D.,Choi C.H.,Bark H.,Son H.Y.,Park H.H.,Lee S.,and Kim S.H.,2007,Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38MAPK in HMC-1 human mast cell line,Inflammation Research,56(5):210-215
Morton J.F.,1992,The ocean-going noni,or Indian Mulberry(Morinda citrifolia,Rubiaceae)and some of its“colorful”relatives,Economic Botany,46(3):241-256
Muto J.,Hosung L.,Uwaya A.,Isami F.,Ohno M.,and Mikami T.,2010,Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice.Physiology and Behavior,101(2):211-217
Neubauer O.,Reichhold S.,Nersesyan A.,K觟nig D.,and Wagner K.H.,2008,Exercise-induced DNA damage:is there a relationship with in覲ammatory responses,Exercise Immunology Review,14(1):51-72
Nie J.,Tong T.K.,George K.,Fu F.H.,Lin H.,and Shi Q.,2011,Resting and post-exercise serum biomarkers of cardiac and skeletal muscle damage in adolescent runners,Scandinavian Journal of Medicine and Science in Sports,21(5):625-629
Nualsanit T.,Rojanapanthu P.,Gritsanapan W.,Kwankitpraniti T.,Min K.W.,and Baek S.J.,2011,Damnacanthal-induced anti-in覲ammation is associated with inhibition of NF-κB activity,In覲ammation and Allergy Drug Targets,10(6):455-463
Nuviala R.,Roda L.,Lapieza M.,Boned B.,and Giner A.,1992,Serum enzymes activities at rest and after a marathon race,The Journal of Sports Medicine and Physical Fitness,32(2):180-186
Palu A.K.,West B.J.,and Jensen J.,2011,Nonibased nutritional supplementation and exercise interventions in覲uence body composition,North American Journal of Medical Sciences,3(12):552-556
Pawlus A.D.,Su B.N.,Keller W.J.,and Kinghorn A.D.,2005,An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolianoni,Journal of Natural Products,68(12):1720-1722
Peake J.M.,Suzuki K.,and Coombes J.S.,2007,The in覲uence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise,The Journal of Nutritional Biochemistry,18(6):357-371
Rosa-Lima F.L.,Lannes L.,Viana-Gomes D.,Pierucci A.P.,and Salerno V.P.,2015,Protein carbonyl levels correlate with performance in elite feld hockey players,Applied Physiology,Nutrition,and Metabolism,40(7):683-688
Sakr H.F.,Abbas A.M.,Elsamanoudy A.Z.,and Ghoneim F.M.,2015,Effect of覲uoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stressinduced depression,Journal of Physiology and Pharmacology,66(4):515-527
Schr觟der H.,Navarro E.,Mora J.,Galiano D.,and Tramullas A.,2001,Effects ofα-tocopherol,β-carotene and ascorbic acid on oxidative,hormonal and enzymatic exercise stress markers in habitual training activity of professional basketball players,European Journal of Nutrition,40(4):178-184
Serafni M.R.,Santos R.C.,Guimaraes A.G.,dos Santos J.P.A.,da Conceicao Santos A.D.,Alves I.A.,and de Souza Araújo A.A.,2011,Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive.behavior and leukocyte migration.Journal of Medicinal Food,14(10):1159-1166
Singh D.R.,Sunder J.,and Srivastava R.C.,2008,Peptide and mineral profle of Morinda citrifolia fruits and leaves.International Journal of Noni Research,2(1-2):72-78
Soeder G.,Golf S.W.,Graef V.,Temme H.,Brüstle A.,Róka L.,and Ibe K.,1989,Enzyme catalytic concentrations in human plasma after a marathon,Clinical Biochemistry,22(2):155-159
Wang M.Y.,Peng L.,Jensen C.J.,Deng S.,and West B.J.,2013,Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers,Food Science and Nutrition,1(2):141-149
Wang M.Y.,Peng,L.,Weidenbacher-Hoper V.,Deng S.,Anderson G.,and West B.J.,2012,Noni juice improves serum lipid profles and other risk markers in cigarette smokers,The Scientifc World Journal,2012(21):594657
Welc S.S.,and Clanton T.L.,2013,The regulation of interleukin-6 implicates skeletal muscle as an integrative stress sensor and endocrine organ,Experimental Physiology,98(2):359-371
West B.J.,White L.D.,Jensen C.J.,and Palu A.K.,2009,A double-blind clinical safety study of noni fruit juice,Pacifc Health Dialog,15(2):21-32
Whyte G.,George K.,Shave R.,Dawson E.,Stephenson C.,Edwards B.,and Simspon R.,2005,Impact of marathon running on cardiac structure and function in recreational runners,Clinical Science,108(1):73-80
Wu H.,Chen K.,Shee B.,Chang H.,Huang Y.,and Yang R.,2004,Effects of 24 h ultra-marathon on biochemical and hematological parameters,World Journal of Gastroenterology:World Journal of Gastroenterology,10(18):2711-2714
Ziegler M.,Braumann K.M.,and Reer R.,2004,The role of jogging in the prevention and treatment of cardiovascular disease,MMW Fortschritte der Medizin,146(8):29-32
基本信息:
DOI：10.13417/j.gab.037.005201
中图分类号:R87
引用信息:
[1]高鹏,郭宏焘,姜小峰.诺丽果对男性大学生长跑运动后氧化伤害的影响[J].基因组学与应用生物学,2018,37(11):5201-5208.DOI:10.13417/j.gab.037.005201.
基金信息:
延安大学体育学院资助
2018-11-25
2018-11-25