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为探讨乳腺癌手术后出现切口感染的患者采用强化护理对患者炎症因子、生存质量的影响,本研究选取实施乳腺癌根治手术后并发切口感染的114例患者作为研究对象,所有患者均采用抗感染基础治疗,其中57例患者治疗期间同时给予强化护理(强化组)、另外57例给予常规护理(常规组)。通过对比两组干预前、干预5 d后的血清炎症因子水平、生存质量评分,本研究发现干预前强化组和常规组的血清IL-4、IL-8、IL-10、CRP、TNF-α水平差异无统计学意义(p>0.05);干预后,强化组的血清IL-4、IL-8、IL-10、CRP、TNF-α水平均显著的低于常规组(p<0.05);干预后,两组的血清IL-4、IL-8、IL-10、CRP、TNF-α水平较本组干预前均显著的降低(p<0.05);干预后,强化组的情绪功能、躯体功能、认知功能、角色功能、社会功能、总体健康状况均显著的高于常规组(p<0.05);强化组的疲倦、疼痛、呼吸困难、睡眠、食欲丧失、便秘评分显著的低于常规组(p<0.05);两组患者的恶心呕吐、经济领域评分差异无统计学意义(p>0.05)。本研究的结果说明,乳腺癌手术后出现切口感染的患者采用强化护理有利于抗炎治疗,同时改善患者的生存质量,具有较好的临床推广价值。
Abstract：To investigate the effect of intensive care on inflammatory factors and quality of life in patients with incision infection after breast cancer surgery, 114 cases of breast cancer patients who had incision infection after surgery had been taken as the research objects. All patients were treated with antiinfection therapy, and 57 cases of which were given intensive nursing care during treatment, while other 57 cases were given routine nursing(normal group). By comparing the serum levels of inflammatory factors and quality of life scores between the two groups before the intervention and after 5 days, it was found that before the intervention, no significant differences were observed in the serum levels of IL-4, IL-8, IL-10, CRP, and TNF-α between enhancement group and normal group(p>0.05); after the intervention, the serum levels of IL-4, IL-8, IL-10, CRP, and TNF-α in enhancement group were significantly lower than normal group(p<0.05); after the intervention, the serum levels of IL-4, IL-8, IL-10, CRP, and TNF-α in each group were significantly lower than before(p<0.05); after the intervention,emotional function, physical function, role function, cognitive function, social function and overall health status in enhancement group were significantly higher than the normal group(p<0.05); and the fatigue, pain, dyspnea, sleep,loss of appetite, constipation score in enhancement group were significantly lower than that of the normal group(p<0.05); no significant differences were observed in the score of nausea and vomiting, and economic field between two groups(p>0.05). It could be concluded that in this study intensive care is beneficial to the anti-inflammatory treatment and the quality of life of the patients with incision infection after breast cancer surgery, and has good clinical application value.
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基本信息:
DOI：10.13417/j.gab.037.005043
中图分类号:R473.73
引用信息:
[1]孙志霞,刘京.应用强化护理可改善乳腺癌术后切口感染[J].基因组学与应用生物学,2018,37(11):5043-5049.DOI:10.13417/j.gab.037.005043.
基金信息:
河北省中医院资助
2018-11-25
2018-11-25