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为了探讨壳聚糖创面修复膜凝胶治疗浅Ⅱ度烧伤对患者创面愈合及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、细胞间黏附分子-1(ICAM-1)水平的影响,本研究选取在我院(2014年4月至2016年4月)收治的97例浅Ⅱ度烧伤患者作为研究对象,所有患者均采用抗感染、保暖、止痛、补液等基础治疗,其中49例患者加用壳聚糖创面修复膜凝胶治疗(治疗组)、48例患者采用凡士林油纱布包扎(对照组),对比两组的创面愈合情况、疼痛评分、瘢痕形成情况、血清TNF-α、IL-10、ICAM-1水平。研究发现,治疗组在治疗第7天、第14天的创面愈合率显著高于对照组,具有统计学意义(p<0.05);在创面愈合时间上治疗组的显著短于对照组,具有统计学意义(p<0.05);在疼痛程度评分上,治疗组在治疗第7天、第14天时均显著低于对照组,差异具有统计学意义(p<0.05);治疗前,治疗组和对照组的血清TNF-α、IL-10、ICAM-1水平差异均无统计学意义(p>0.05);治疗7 d后,治疗组患者的血清TNF-α、IL-10、ICAM-1水平显著低于对照组(p<0.05);治疗后3个月、6个月,治疗组的瘢痕评分均低于同期对照组患者,差异具有统计学意义(p<0.05)。壳聚糖创面修复膜凝胶治疗浅Ⅱ度烧伤具有促进创面愈合、减轻烧伤患者炎症反应程度的作用。
Abstract：The purpose of this study was to explore the effect of chitosan hydrogel dressing on wound healing of burn treatment and serum tumor necrosis factor alpha(TNF-alpha), superficial interleukin-10(IL-10), intercellular adhesion molecule-1(ICAM-1) level. We selected 97 cases of patients with shallow two degree burn in our hospital(April 2014 to April 2016), all of which were treated with anti-infection, warmth, pain, rehydration therapy.49 cases of them were added with chitosan hydrogel dressing treatment(treatment group), whereas 48 patients were added with vaseline gauze cloth dressing(control group comparing the two groups), then we compared wound healing, pain, scar formation, and serum TNF-α, IL-10, ICAM-1. It was found that in the treatment group for the seventh days, fourteenth days the wound healing rate was significantly higher than that of control group,the difference was statistically significant(p<0.05). Wound healing time of the treatment group was shorter than the control group, and the difference was statistically significant(p<0.05). The pain VAS scores in the treatment group of seventh days, fourteenth days were significantly lower than those in the control group, and the difference was statistically significant(p<0.05). Before the treatment, serum TNF-α, IL-10 and ICAM-1 levels of the treatment group and the control group showed no significant difference(p>0.05). After 7 days of treatment, serum TNF-α,IL-10 and ICAM-1 in the treatment group were significantly lower than the control group(p<0.05) 3 and 6 months after treatment, scar scores in the treatment group were lower than those in the control group at the same period,and the difference was statistically significant(p <0.05). It was indicated that chitosan wound membrane gel treatment of superficial second degree burns might promote wound healing and reduce the inflammatory reaction in burn patients.
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基本信息:
DOI：10.13417/j.gab.036.004867
中图分类号:R644
引用信息:
[1]曾明.壳聚糖创面修复膜凝胶治疗Ⅱ度烧伤的效果及对血清炎症因子水平的影响[J].基因组学与应用生物学,2017,36(12):4867-4873.DOI:10.13417/j.gab.036.004867.
基金信息:
昆明医科大学第二附属医院资助
2017-09-06
2017-09-06
2017-09-06