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微小RNA (microRNAs, miRNAs)是一类内源性的、长度在19～25个核苷酸的单链非编码小RNA分子，在生物体内主要参与基因转录后水平的表达调控。研究证实，同一miRNA可以靶向多种不同的基因，同一基因也可以由多个miRNAs调控，miRNA与其靶基因形成的互作模体(motifs)不仅可以调控生物的生长发育，在生殖、代谢和疾病发生等多个方面也具有重要的作用。本研究从miRNA靶基因的鉴定，miRNA调控靶基因的方式以及水产动物中“miRNA-靶基因”模体的研究进展3个方面进行综述，旨在为系统掌握水产动物miRNA对其靶基因的调控特点及规律，探讨水产动物中“miRNA-靶基因”模体参与水产动物重要生理生化过程的分子机制提供更多参考。
Abstract：microRNAs(miRNAs) are a class of endogenous small non-coding RNAs with length of about 19～25 nucleotides. miRNAs mainly are involved in gene expression regulation at post-transcriptional level. It has been demonstrated that a given miRNA might have multiple different gene targets, and a given gene might be targeted by multiple miRNAs. "miRNA-gene" interaction motifs have been documented play important regulatory roles in the development, reproductive processes, cell proliferation and apoptosis, metabolic processes and diseases in eukaryotic organisms. In this study, we reviewed the identification of miRNA target gene, the way of miRNA regulating target gene and the research progress of "miRNA-gene" motif in aquatic animals so that we can further understand biological roles of miRNAs in aquatic animals systematically, and also, it can help us explore the molecular mechanisms of "miRNA-gene" motifs participating in important physiological and biochemical processes.
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基本信息:
DOI：10.13417/j.gab.040.002590
中图分类号:S917.4
引用信息:
[1]任丽媛,赵谭军,尹文露,等.水产动物“miRNA-靶基因”模体(motif)生物功能研究进展[J].基因组学与应用生物学,2021,40(Z2):2590-2599.DOI:10.13417/j.gab.040.002590.
基金信息:
国家重点研发计划资助项目(2018YFD0900105); 中国水产科学研究院院级基本科研业务费-农业部海洋渔业可持续发展重点实验室开放课题(2019HY-XKQ01)共同资助
2020-03-26
2020-03-26
2020-03-26