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RNA修饰是表观遗传学调控的重要组成部分，在生命活动中发挥着极其重要的调控作用。随着RNA修饰检测技术的发展，越来越多的RNA修饰类型被鉴定出来，涉及甲基化修饰、羟甲基化修饰、乙酰化修饰和磷酸化修饰等。这些修饰广泛存在于编码和非编码RNA中，在蛋白翻译调控中发挥重要作用。最近的一些研究显示，建立的RNA修饰可在生殖细胞内形成稳定的遗传传递给子代，当RNA修饰发生异常时，会导致配子发育受阻和胚胎发育阻滞等，这些研究显示了RNA修饰在配子形成及胚胎发育过程中扮演的重要调控角色。本文从RNA修饰种类及生物学特性，RNA修饰蛋白家族及其在配子形成和胚胎发育中的调控作用进行综述，以促进和完善生殖发育调控理论研究。
Abstract：RNA modification is an important part of epigenetic regulation and plays an extremely important regulatory role in life activities. With the development of RNA modification detection technology, more and more RNA modification types have been identified, involving methylation modification, hydroxymethylation modification, acetylation modification and phosphorylation modification. These modifications are widely present in coding and non-coding RNAs and play an important role in protein translation regulation. Recent studies have shown that the established RNA modification can form a stable genetic transmission to offspring in germ cells. When the RNA modification is abnormal, it will lead to gamete development arrest and embryonic development arrest. Some of these studies have shown that RNA modification plays an important regulatory role in gamete formation and embryonic development. This review summarized the types and biological characteristics of RNA modifications, RNA modified protein families, and their regulatory roles in gametogenesis and embryonic development, in order to promote and improve the theoretical research of reproductive development regulation.
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基本信息:
DOI：10.13417/j.gab.042.001146
中图分类号:Q132.4
引用信息:
[1]文君,陈慧芳,乔延召,等.RNA修饰在生殖发育中的研究进展[J].基因组学与应用生物学,2023,42(11):1146-1158.DOI:10.13417/j.gab.042.001146.
基金信息:
广东省重点领域研发计划(2021B0707010007); 广东省基础与应用基础研究基金项目(2022A1515011185)共同资助
2023-07-17
2023-07-17
2023-07-17