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本研究基于当代中国人群3D牙齿模型数据，参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America, CANDELA)所使用的牙齿特征点标记方法，使用牙齿特征点间的欧几里得线性距离(Euclidean linear distances, ELD)表示的牙齿表型作为牙齿可观测特征的度量，探究个体因素(年龄、性别)和群体因素(民族)对当代中国人群牙齿可观测特征多样性的影响。通过对牙齿标记特征点的典型变量分析(canonical variate analysis, CVA)、交叉验证(cross validation, CV)、主成分分析(principal component analysis, PCA)以及对牙齿表型的Pearson相关性分析和差异分析，本研究发现进化上相近的群体牙齿可观测特征往往更接近。具体来说，汉族的上颌牙齿可观测特征和壮族、苗族较为接近而不同于蒙古族的，而藏族的上、下颌牙齿可观测特征不同于维吾尔族的；南北中汉族牙齿表型的差异具有明确的方向性，下颌牙齿差异比上颌更明显；从性别角度看，男女牙齿表型差异主要体现在尖牙上，男性尖牙平均宽度和高度显著大于女性的；对不同年龄群体的差异分析表明，遗传外因素对牙齿可观测特征的影响主要体现在尖牙、上颌第一磨牙、下颌第一前磨牙上。
Abstract：This study is based on the 3D dental models data of contemporary Chinese groups, and dental landmarking method is used in this study, which is used by the consortium for the analysis of the diversity and evolution of Latin America(CANDELA). Dental phenotypes represented by Euclidean linear distances(ELD) between landmarks in this study are basis of measurement of dental diversity. This study aims to explore the impact of individual factors(age and gender) and population factor(ethnic groups) on the dental diversity among contemporary Chinese groups. The results of canonical variate analysis(CVA), cross validation(CV), principal component analysis(PCA), Pearson correlation analysis and differences analysis showed that the dental observable characteristics of populations which had closer evolutionary relationships were often more similar. Specifically, the dental observable characteristics of upper teeth of Han nationality are closer to those of Zhuang and Miao nationalities but different from that of Mongolian nationality, and the dental observable characteristics of upper and lower teeth of Tibetan nationality are different from those of Uyghur nationality. The differences in dental phenotypes of southern/northern/central Han Chinese were clearly directional, and the differences of mandibular teeth was more obvious than that of maxillary teeth. From the perspective of gender, the differences of dental phenotypes between men and women were mainly reflected in the canines, and the average width and height of male canines were significantly greater than that of female canines. The differences analysis among different age groups showed that the influence of extragenetic factors on the dental observable characteristics was mainly reflected in the canines, maxillary first molars and mandibular first premolars.
ADHIKARI K,FONTANIL T,CAL S,et al.,2016.A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features.Nat.Commun.,7:10815.
BERTHAUME M,GROSSE I R,PATEL N D,et al.,2010.The effect of early hominin occlusal morphology on the fracturing of hard food items.Anat.Rec.(Hoboken),293(4):594-606.
BISHARA S E,TREDER J E,JAKOBSEN J R,1994.Facial and dental changes in adulthood.Am.J.Orthod.Dentofacial Orthop.,106(2):175-186.
CARTER G A,MCNAMARA J A Jr,1998.Longitudinal dental arch changes in adults.Am.J.Orthod.Dentofacial Orthop.,114(1):88-99.
DOS SANTOS C C O,DA ROSA MOREIRA BASTOS R T,BELLINI-PEREIRA S A,et al.,2023.Spontaneous changes in mandibular incisor crowding from mixed to permanent dentition:a systematic review.Prog.Orthod.,24(1):15.
EDGAR H J H,2013.Estimation of ancestry using dental morphological characteristics.J.Forensic Sci.,58(Suppl 1):S3-S8.
FENG Q D,LU Y,NI X M,et al.,2017.Genetic history of Xinjiang′s uyghurs suggests bronze age multiple-way contacts in Eurasia.Mol.Biol.Evol.,34(10):2572-2582.
GARIB D,MIRANDA F,MASSARO C,et al.,2021.Three-dimensional mandibular dental changes with aging.Am.J.Orthod.Dentofacial Orthop.,159(2):184-192.
KONG-ZáRATE C Y,CARRUITERO M J,ANDREWS W A,2017.Distances between mandibular posterior teeth and the WALA ridge in Peruvians with normal occlusion.Dental Press J.Orthod.,22(6):56-60.
MASSARO C,MIRANDA F,JANSON G,et al.,2018.Maturational changes of the normal occlusion:a 40-year follow-up.Am.J.Orthod.Dentofacial Orthop.,154(2):188-200.
MIRANDA F,MASSARO C,JANSON G,et al.,2019.Aging of the normal occlusion.Eur.J.Orthod.,41(2):196-203.
PAN Z Q,XU S H,2020.Population genomics of East Asian ethnic groups.Hereditas,157(1):49.
QIN P F,ZHOU Y,LOU H Y,et al.,2015.Quantitating and dating recent gene flow between European and East Asian populations.Sci.Rep.,5:9500.
RUIZ-LINARES A,ADHIKARI K,ACU?A-ALONZO V,et al.,2014.Admixture in Latin America:geographic structure,phenotypic diversity and self-perception of ancestry based on 7,342 individuals.PLoS Genet.,10(9):e1004572.
SINCLAIR P M,LITTLE R M,1983.Maturation of untreated normal occlusions.Am.J.Orthod.,83(2):114-123.
TAN J Z,PENG Q Q,LI J X,et al.,2014.Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant.Sci.China Life Sci.,57(5):510-518.
TOWNSEND G,HUGHES T,LUCIANO M,et al.,2009.Genetic and environmental influences on human dental variation:a critical evaluation of studies involving twins.Arch.Oral Biol.,54(Suppl 1):S45-S51.
TRIVI?O T,SIQUEIRA D F,SCANAVINI M A,2008.A new concept of mandibular dental arch forms with normal occlusion.Am.J.Orthod.Dentofacial Orthop.,133(1):e15-e22.
WANG Y C,LU D S,CHUNG Y J,et al.,2018.Genetic structure,divergence and admixture of Han Chinese,Japanese and Korean populations.Hereditas,155:19.
WELLS R S,YULDASHEVA N,RUZIBAKIEV R,et al.,2001.The Eurasian heartland:a continental perspective on Y-chromosome diversity.Proc.Natl.Acad.Sci.USA,98(18):10244-10249.
WOON C K,JAMAL N A A,NOOR M N I M,et al.,2019.Geometric morphometric analysis of malocclusion on lateral cephalograms in Malaysian population.Anat.Cell Biol.,52(4):397-405.
XU S H,YIN X Y,LI S L,et al.,2009.Genomic dissection of population substructure of Han Chinese and its implication in association studies.Am.J.Hum.Genet.,85(6):762-774.
YANG G R,CHEN Y,LI Q,et al.,2023.Dental size variation in admixed Latin Americans:effects of age,sex and geno-mic ancestry.PLoS ONE,18(5):e0285264.
YANG M Q,HE G L,REN Z,et al.,2022.Genomic insights into the unique demographic history and genetic structure of five hmong-mien-speaking Miao and Yao populations in southwest China.Front.Ecol.Evol.,10:849195.
YANG X M,WANG X X,HE G L,et al.,2021.Genomic insight into the population history of Central Han Chinese.Ann.Hum.Biol.,48(1):49-55.
YAO Y G,KONG Q P,WANG C Y,et al.,2004.Different matrilineal contributions to genetic structure of ethnic groups in the silk road region in China.Mol.Biol.Evol.,21(12):2265-2280.
ZHAO Z J,2010.New data and new issues for the study of origin of rice agriculture in China.Archaeol.Anthropol.Sci.,2(2):99-105.
基本信息:
DOI：10.13417/j.gab.043.000150
中图分类号:Q983
引用信息:
[1]罗浩,陈颖洁,杨光睿,等.当代中国人群牙齿可观测特征的多样性研究[J].基因组学与应用生物学,2024,43(01):150-171.DOI:10.13417/j.gab.043.000150.
基金信息:
国家自然科学基金项目(31771393)资助
2023-09-19
2023-09-19
2023-09-19