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犬细小病毒病(Canine parvovirus disease, CPVD)是由犬细小病毒(Canine parvovirus, CPV)引起的一种犬(Canis lupus familiaris)的急性、烈性、高致死性传染病。该病虽有疫苗进行防控，但仍有免疫失败的案例被报道。CPV的致病机制及宿主的防御机理还未完全阐明。尽管单个基因、蛋白和通路的研究是阐明各种机理的必需研究内容，但各种组学研究也为病毒病相关研究提供了重要的补充和新的理解视角。本文综述了近年来利用各种组学在CPVD相关研究中的进展以及所揭示的机制，以便更系统地从组学角度理解CPV与宿主之间的互作机制，探索更多可用于CPVD研究的组学方法，为CPVD的病理、防御、治疗等研究提供参考。
Abstract：Canine parvovirus disease(CPVD) is an acute, potent, highly lethal infectious disease in Canis lupus familiaris caused by Canine parvovirus(CPV). Although it is mainly prevented by vaccination, cases of vaccination failure have still been reported. The pathogenic mechanism of CPV and the defense mechanism of the host have not been fully elucidated. Although research studies of single gene, protein and pathway are necessary for clarifying the multiple mechanisms, omics approaches also provide important supplements, as well as new perspectives to the investigation of viral diseases. This article reviews the advances in various omics researches used in CPVD and the mechanisms revealed in recent years, in order to systematically understand the interplay between CPV and host from omics perspective, explore more possibilities of using omics methods in CPVD research, and provide references for the research on the pathology, defense, and treatment of CPVD.
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基本信息:
DOI：10.13417/j.gab.044.000219
中图分类号:S852.655
引用信息:
[1]艾馨,王浩荣,张亦凡等.犬细小病毒病的组学研究进展[J].基因组学与应用生物学,2025,44(03):219-228.DOI:10.13417/j.gab.044.000219.
基金信息:
吉林省教育厅科学研究项目(JJKH20231143KJ);吉林省教育厅“十三五”科学技术项目(JJKH20200521KJ)共同资助; 吉林省自然科学基金项目(20210101368JC)