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真核细胞周期调控和检验点机制是目前生物学研究的热点。模式生物酿酒酵母(Saccharomyces cerevisiae)细胞周期运转的研究为哺乳动物和其他真核生物细胞周期调控的研究提供了基础信息。细胞周期与细胞的形态变化(morphogenesis)间存在一定的关系。本研究介绍了酿酒酵母形态变化检验点(morphogenesis checkpoint)的研究进展。当细胞形态发生缺陷时,形态变化检验点对其做出响应,延迟细胞核分裂,直到芽体正常形成。该延迟过程是通过抑制CDK抑制蛋白激酶(CDK-inhibitory kinase)Swe1p的降解来实现的。Swe1p的作用是通过抑制Clb-Cdc28p的活性,调节细胞周期进程。细胞形态变化和细胞周期间的正确交流对保证细胞的成功分裂起到关键作用。虽然目前已取得了一定的进展,但仍有许多问题有待进一步研究。
Abstract：Cell cycle regulation and checkpoint control is one of the research fields that has attracted a great deal of efforts in biological sciences. The studies on the cell cycle regulation in the yeast Saccharomyces cerevisiae had provided foundational information for the research in mammalian and other eukaryotic cells. It had been recognized that yeast cell morphogenesis was correlated with the cell cycle. Here we reviewed the understanding of morphogenesis checkpoint in Saccharomyces cerevisiae. Morphogenesis checkpoint responses to morphogenesis defects and delays nuclear division until a bud had been formed. The delay was caused by blocking the degradation of the CDK-inhibitory kinase Swe1 p. Swe1 p inhibits Clb-Cdc28 p activity, which regulate cell cycle progression.The communication between morphogenesis and the cell cycle is crucial for successful proliferation. Despite considerable progress, however, there are still many questions needing to be resolved.
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基本信息:
DOI：10.13417/j.gab.035.001177
中图分类号:Q93
引用信息:
[1]祝嫦巍,史钧.酿酒酵母形态变化检验点的研究进展[J].基因组学与应用生物学,2016,35(05):1177-1182.DOI:10.13417/j.gab.035.001177.
基金信息:
安徽省自然科学基金(1408085MC41)资助
2016-05-25
2016-05-25