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2020, 09, v.39 4171-4177
植物MYB转录因子调控次生代谢的研究进展
基金项目(Foundation): 国家高技术研究发展计划(863计划)项目(2013AA102604-3);; 吉林省发改委-吉林省省级产业创新专项(2016C04;2018C047-3);; 吉林省科技厅自然基金项目(20170101010JC;20180101027JC);吉林省科技厅国际合作项目(201804-14077GH)共同资助
邮箱(Email): mpzhang@exchange.tam;
DOI: 10.13417/j.gab.039.004171
发布时间: 2020-09-25
出版时间: 2020-09-25
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摘要:

转录因子调节是植物基因表达和调节机制的重要组成部分,MYB转录因子(V-myb avian myeloblastosis viral oncogene homolog),是植物中最大转录因子家族之一。MYB转录因子对多种次生代谢产物的生物合成具有转录调控作用,如硫代葡萄糖苷、黄酮类、萜类、木质素类和芪类化合物等。本综述将对MYB转录因子家族对植物次生代谢的影响作详细阐述,以期为后续进一步探究该转录因子家族基因的功能提供理论参考。

关键词: MYB; 调控; 次生代谢;
Abstract:

The transcription factor regulation is an important part of plant gene expression and regulation mechanism. MYB transcription factor(v-myb avian myeloblastosis viral oncogene homolog) is one of the largest families of transcription factors in plants. A variety of secondary metabolites is regulated by MYB transcription factors, such as the biosynthesis of glucosinolates, flavonoids, terpenoids, lignins and stilbenes. To provide reference for further exploration of the function, this review focuses on the influence of the MYB transcription factor family on plant secondary metabolism.

参考文献

Ahmed N.U.,Park J.I.,Jung H.J.,Hur Y.,and Nou I.S.,2015,Anthocyanin biosynthesis for cold and freezing stress tolerance and desirable color in Brassica rapa,Functional Integrative Genomics,15(4):383-394

Ambawat S.,Sharma P.,and Yadav N.R.,2013,MYB transcription factor genes as regulators for plant responses:An overview,Physiol.Mol.Biol.Plants,19(3):307-321

Augustine R.,Majee M.,and Gershenzon J.,2013,Four genes encoding MYB28,a major transcriptional regulator of the aliphatic glucosinolate pathway,are differentially expressed in the allopolyploid Brassica juncea,J.Exp.Bot.,64(16):4907-4921

Boerjan W.,Ralph J.,and Baucher M.,2003,Lignin biosynthesis,Ann.Review Plant Biol.,54(1):519-546

Bogs J.,Jaffe F.W.,Takos A.M.,Walker A.R.,and Robinson S.P.,2007,The grapevine transcription factor Vv MYBPA1 regulates proanthocyanidin synthesis during fruit development,Plant Physiol.,143(3):1347-1361

Borevitz J.O.,Xia Y.,Blount J.,Dixon R.A.,and Lamb C.,2000,Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis,Plant Cell,12(12):2383-2393

Bouvier F.,Rahier A.,and Camara B.,2005,Biogenesis,molecular regulation and function of plant isoprenoids,Progress in Lipid Research,44(6):357-429

Celenza J.L.,Quiel J.A.,Smolen G.A.,Merrikh H.,Silvestro A.R.,Normanly J.,and Bender J.,2005,The Arabidopsis A-TR1 Myb transcription factor controls indolic glucosinolate homeostasis,Plant Physiol.,137(1):253-262

Cho J.S.,Nguyen V.P.,and Jeon H.W.,2016,Overexpression of Ptr MYB119,a R2R3-MYB transcription factor from Populustrichocarpa,promotes anthocyanin production in hybrid poplar,Tree Physiol.,36(9):1162-1176

Chong J.,Poutaraud A.,and Hugueney P.,2009,Metabolism and roles of stilbenes in plants,Plant Sci.,177(3):143-155

Czemmel S.,Stracke R.,Weisshaar B.,Cordon N.,Harris N.N.,Walker A.R.,Robinson S.P.,and Bogs J.,2009,The grapevine R2R3-MYB transcription factor Vv MYBF1 regulates flavonol synthesis in developing grape berries,Plant Physiol.,151(3):1513-1530

Deluc L.,Barrieu F.,Marchive C.,Lauvergeat V.,Decendit A.,Richard T.,Carde J.P.,Mérillon J.M.,and Hamdi S.,2006,Characterization of a grapevine R2R3-MYB transcription factor that regulates the phenylpropanoid pathway,Plant Physiol.,140(2):499-511

Dubos C.,Stracke R.,and Grotewold E.,2010,MYB transcription factors in Arabidopsis,Trends in Plant Science,15(10):573-581

Falcone Ferreyra M.L.,Rius S.,Emiliani J.,Pourcel L.,Feller A.,Morohashi K.,Casati P.,and Grotewold E.,2010,Cloning and characterization of a UV-B-inducible maize flavonol synthase,Plant J.,62(1):77-91

Feng K,Liu J.X.,Duan A.Q.,Li T.,Yang Q.Q.,Xu Z.S.,and Xiong A.S.,2018,Ag MYB2 transcription factor is involved in the regulation of anthocyanin biosynthesis in purple celery(Apium graveolens L),Planta,248(5):1249-1261

Fornale S.,Shi X.,Chai C.,Encina A.,Irar S.,Capellades M.,Fuguet E.,Torres J.L.,Rovira P.,Puigdomènech P.,Rigau J.,Grotewold E.,Gray J.,and Caparrós-Ruiz D.,2010,ZmMYB31 directly represses maize lignin genes and redirects the phenylpropanoid metabolic flux,Plant J.,64(4):633-644

Frerigmann H.,and Gigolashvili T.,2014,MYB34,MYB51,and MYB122 distinctly regulate indolic glucosinolate biosynthesis in Arabidopsis thaliana,Mol.Plant,7(5):814-828

Frerigmann H.,Berger B.,and Gigolashvili T.,2014,BHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis,Plant Physiol.,166(1):349-369

Gigolashvili T.,Berger B.,Mock H.P.,Müller C.,Weisshaar B.,and Flügge U.I.,2007,The transcription factor HIG1/MYB51 regulates indolic glucosinolate biosynthesis in Arabidopsis thaliana,Plant J.,50(5):886-901

Graf T.,1992,Myb:A transcriptional activator linking proliferation and differentiation in hematopoietic cells,Curr.Opin.Genet.Dev.,2(2):249-255

Hirai M.Y.,Sugiyama K.,Sawada Y.,Tohge T.,Obayashi T.,Suzuki A.,Araki R.,Sakurai N.,Suzuki H.,Aoki K.,Goda H.,Nishizawa O.I.,Shibata D.,and Saito K.,2007,Omicsbased identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis,Proc.Natl.Acad.Sci.USA,104(15):6478-6483

Holl J.,Vannozzi A.,Czemmel S.,D'Onofrio C.,Walker A.R.,Rausch T.,Lucchin M.,Boss P.K.,Dry I.B.,and Bogs J.,2013,The R2R3-MYB transcription factors MYB14 and MYB15 regulate stilbene biosynthesis in Vitis vinifera,Plant Cell,25(10):4135-4149

Huang W.J.,Khaldun A.B.,Lv H.Y.,Du L.W.,Zhang C.J.,and Wang Y.,2016,Isolation and functional characterization of a R2R3-MYB regulator of the anthocyanin biosynthetic pathway from Epimedium sagittatum,Plant Cell Rep.,35(4):883-894

CarréI.A.,and Kim J.Y.,2002,MYB transcription factors in the Arabidopsis circadian clock,J.Exp.Bot.,53(374):1551-1557

Jaakola L.,2013,New insights into the regulation of anthocyanin biosynthesis in fruit,Trends in Plant Science,18(9):477-483

Kortstee A.J.,Khan S.A.,and Helderman C.,2011,Anthocyanin production as a potential visual selection marker during plant transformation,Transgenic Research,20(6):1253-1264

Koyama K.,Numata M.,Nakajima I.,Goto-Yamamoto N.,Matsumura H.,and Tanaka N.,2014,Functional characterization of a new grapevine MYB transcription factor and regulation of proanthocyanidin biosynthesis in grapes,J.Exp.Bot.,65(15):4433-4449

Li S.,and Zachgo S.,2013,TCP3 interacts with R2R3-MYB proteins,promotes flavonoid biosynthesis and negatively regulates the auxin response in Arabidopsis thaliana,Plant J.,76(6):901-913

Li X.W.,Li J.W.,Zhai Y.,Zhao Y.,Zhao X.,Zhang H.J.,Su L.T.,Wang Y.,and Wang Q.Y.,2013,A R2R3-MYB transcription factor,Gm MYB12B2,affects the expression levels of flavonoid biosynthesis genes encoding key enzymes in transgenic Arabidopsis,Gene,532(1):72-79

Liu C.Y.,Wang X.,Xu Y.T.,Deng X.X.,and Xu Q.,2014,Genome-wide analysis of the R2R3-MYB transcription factor gene family in sweet orange(Citrus sinensis),Mol.Biol.Rep.,41(10):6769-6785

Luo J.,Butelli E.,Hill L.,Parr A.,Niggeweg R.,Bailey P.,Weisshaar B.,and Martin C.,2008,At MYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato:expression in fruit results in very high levels of both types of polyphenol,Plant J.,56(2):316-326

Ma D.,Reichelt M.,Yoshida K.,Gershenzon J.,and Constabel CP.,2018,Two R2R3-MYB proteins are broad repressors of flavonoid and phenylpropanoid metabolism in poplar,Plant J.,96(5):949-965

Malitsky S.,Blum E.,Less H.,Venger I.,Elbaz M.,Morin S.,Eshed Y.,and Aharoni A.,2008,The transcript and metabolite networks affected by the two clades of Arabidopsis glucosinolate biosynthesis regulators,Plant Physiol.,148(4):2021-2049

Mano H.,Ogasawara F.,and Sato K.,2007,Isolation of a regulatory gene of anthocyanin biosynthesis in tuberous roots of purple-fleshed sweet potato,Plant Physiol.,143(3):1252-1268

Matsui K.,Oshima Y.,Mitsuda N.,Sakamoto S.,Nishiba Y.,Walker A.R.,Ohme-Takagi M.,Robinson S.P.,Yasui Y.,Mori M.,and Takami H.,2018,Buckwheat R2R3 MYBtranscription factor FeMYBF1 regulates flavonol biosynthesis,Plant Sci.,274:466-475

Matus J.T.,2016,Transcriptomic and metabolomic networks in the grape berry illustrate that it takes more than flavonoids to fight against ultraviolet radiation,Front.Plant Sci.,7:1337

Mehrtens F.,Kranz H.,and Bednarek P.,2005,The Arabidopsis transcription factor MYB12 is a flavonol-specific regulator of phenylpropanoid biosynthesis1,Plant Physiol.,138(2):1083-1096

Misra P.,Pandey A.,Tiwari M.,Chandrashekar K.,Sidhu O.P.,Asif M.H.,Chakrabarty D.,Singh P.K.,Trivedi P.K.,Nath P.,and Tuli R.,2010,Modulation of transcriptome and metabolome of tobacco by Arabidopsis transcription factor,At MYB12,leads to insect resistance,Plant Physiol.,152(4):2258-2268

Nakatsuka T.,Saito M.,Yamada E.,Fujita K.,Kakizaki Y.,and Nishihara M.,2012,Isolation and characterization of GtMYBP3 and Gt MYBP4,orthologues of R2R3-MYB transcription factors that regulate early flavonoid biosynthesis,in gentian flowers,J.Exp.Bot.,63(18):6505-6517

Nesi N.,Jond C.,Debeaujon I.,Caboche M.,and Lepiniec L.,2001,The Arabidopsis TT2 gene encodes an R2R3 MYBdomain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed,Plant Cell,13(9):2099-2114

Niu Y.L.,Jiang X.M.,and Xu X.Y.,2016,Advances in research on plant transcription factor MYB gene family,Fenzi Zhiwu Yuzhong(Molecular Plant Breeding),14(8):2050-2059(牛义岭,姜秀明,许向阳,2016,植物转录因子MYB基因家族的研究进展,分子植物育种,14(8):2050-2059)

Oh J.E.,Kim Y.H.,and Kim J.H.,2011,Enhanced level of anthocyanin leads to increased salt tolerance in Arabidopsis PAP1-D plants upon sucrose treatment,Journal of the Korean Society for Applied Biological Chemistry,54(1):79-88

Omer S.,Kumar S.,and Khan B.M.,2013,Over-expression of a subgroup 4 R2R3 type MYB transcription factor gene from Leucaena leucocephala reduces lignin content in transgenic tobacco,Plant Cell Rep.,32(1):161-171

Pandey A.,Misra P.,Chandrashekar K.,and Trivedi P.K.,2012,Development of At MYB12-expressing transgenic tobacco callus culture for production of rutin with biopesticidal potential,Plant Cell Rep.,31(10):1867-1876

Pandey A.,Misra P.,Khan M.P.,Swarnkar G.,Tewari M.C.,Bhambhani S.,Trivedi R.,Chattopadhyay N.,and Trivedi P.K.,2014,Co-expression of Arabidopsis transcription factor,At MYB12,and soybean isoflavone synthase,GmIFS1,genes in tobacco leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotective activity,Plant Biotechnol.,12(1):69-80

Paz-Ares J.,Ghosal D.,Wienand U.,Peterson P.A.,and Saedler H.,1987,The regulatory C1 locus of Zea mays encodes a protein with homology to MYB-related proto-oncogene products and with structural similarities to transcriptional activators,EMBO J.,6(12):3553-3558

Reddy V.A.,Wang Q.,Dhar N.,Kumar N.,Venkatesh P.N.,Rajan C.,Panicker D.,Sridhar V.,Mao H.Z.,and Sarojam R.,2017,Spearmint R2R3-MYB transcription factor Ms MYBnegatively regulates monoterpene production and suppresses the expression of geranyl diphosphate synthase large subunit(Ms GPPS.LSU),Plant Biotechnol.J.,15(9):1105-1119

Robin A.H.K.,Yi G.E.,and Laila R.,2016,Expression profiling of glucosinolate biosynthetic genes in Brassica oleracea L.var.capitata inbred lines reveals their association with glucosinolate content,Molecules,21(6):787

Rommens C.M.,Richael C.M.,Yan H.,Navarre D.A.,Ye J.,Krucker M.,and Swords K.,2008,Engineered native pathways for high kaempferol and caffeoylquinate production in potato,Plant Biotechnol.,6(9):870-886

Sarma A.D.,1999,Anthocyanin-DNA copigmentation complex:mutual protection against oxidative damage,Phytochem.,52(7):1313-1318

Schweizer F.,Fernández-Calvo P.,Zander M.,Diez-Diaz M.,Fonseca S.,Glauser G.,Lewsey M.G.,Ecker J.R.,Solano R.,and Reymond P.,2013,Arabidopsis basic helix-loop-helix transcription factors MYC2,MYC3,and MYC4 regulate glucosinolate biosynthesis,insect performance,and feeding behavior,Plant Cell,25(8):3117-3132

Seo M.S.,Jin M.,and Chun J.H.,2016,Functional analysis of three Br MYB28 transcription factors controlling the biosynthesis of glucosinolates in Brassica rapa,Plant Mol.Biol.,90(4-5):503-516

Shen H.,He X.Z.,Poovaiah C.R.,Wuddineh W.A.,Ma J.Y.,Mann D.G.,Wang H.Z.,Jackson L.,Tang Y.H.,Stewart C.N.Jr,Chen F.,and Dixon R.A.,2012,Functional characterization of the switchgrass(Panicum virgatum)R2R3-MYBtranscription factor Pv MYB4 for improvement of lignocellulosic feedstocks,New Phytol.,193(1):121-136

Sonderby I.E.,Burow M.,Rowe H.C.,Kliebenstein D.J.,and Halkier B.A.,2010,A complex interplay of three R2R3MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis,Plant Physiol.,153(1):348-363

Stracke R.,Werber M.,and Weisshaar B.,2001,The R2R3-MYBgene family in Arabidopsis thaliana,Curr.Opin.Plant Biol.,4(5):447-456

Stracke R.,Ishihara H.,Huep G.,Barsch A.,Mehrtens F.,Niehaus K.,and Weisshaar B.,2007,Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling,Plant J.,50(4):660-677

Takos A.M.,Jaffe F.W.,Jacob S.R.,Bogs J.,Robinson S.P.,and Walker A.R.,2006,Light-induced expression of a MYBgene regulates anthocyanin biosynthesis in red apples,Plant Physiol.,142(3):1216-1232

Tamagnone L.,Merida A.,Parr A.,Mackay S.,Culianez-Macia F.A.,Roberts K.,and Martin C.,1998,The Am MYB308and Am MYB330 transcription factors from antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobacco,Plant Cell,10(2):135-154

Terrier N.,Torregrosa L.,Ageorges A.,Vialet S.,Verries C.,Cheynier V.,and Romieu C.,2008,Ectopic expression of Vv MybPA2 promotes proanthocyanidin biosynthesis in grapevine and suggests additional targets in the pathway,Plant Physiol.,149(2):1028-1041

Tian J.,Peng Z.,Zhang J.,Song T.T.,Wan H.H.,Zhang M.L.,and Yao Y.C.,2015,McMYB10 regulates coloration via activating McF,H and later structural genes in ever-red leaf crabapple,Plant Biotechnol.J.,13(7):948-961

Tohge T.,Nishiyama Y.,and Hirai M.Y.,2005,Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB tran scription factor,Plant J.,42(2):218-235

Xu Q.,Yin X.R.,Zeng J.K.,Ge H.,Song M.,Xu C.J.,Li X.,Ferguson I.B.,and Chen K.S.,2014,Activator-and repressor-type MYB transcription factors are involved in chilling injury induced flesh lignification in loquat via their interactions with the phenylpropanoid pathway,J.Exp.Bot.,65(15):4349-4359

Yi J.,Derynck M.R.,Chen L.,and Dhaubhadel S.,2010a,Differential expression 9 of CHS7 and CHS8 genes in soybean,Planta,231(3):741-753

Yi J.X.,Derynck M.R.,Li X.Y.,Telmer P.,Marsolais F.,and Dhaubhadel S.,2010b,A single-repeat MYB transcription factor,GmMYB176,regulates CHS8 gene expression and affects isoflavonoid biosynthesis in soybean,Plant J.,62(6):1019-1034

Yoshida K.,Ma D.,and Constabel C.P.,2015,The MYB182 protein down-regulates proanthocyanidin and anthocyanin biosynthesis in poplar by repressing both structural and regulatory flavonoid genes,Plant Physiol.,167(3):693-710

Zhong R.,and Ye Z.H.,2009,Transcriptional regulation of lignin biosynthesis,Plant Signaling&Behavior,4(11):1028-1034

Zhong R.Q.,Lee C.H.,Zhou J.L.,McCarthy R.L.,and Ye Z.H.,2008,A battery of transcription factors involved in the regulation of secondary cell wall biosynthesis in Arabidopsis,Plant Cell,20(10):2763-2782

Zhu L.,Shan H.,Chen S.M.,Jiang J.F.,Gu C.S.,Zhou G.Q.,Chen Y.,Song A.P.,and Chen F.D.,2013,The heterologous expression of the Chrysanthemum R2R3-MYB transcription factor Cm MYB1 alters lignin composition and represses flavonoid synthesis in Arabidopsis thaliana,PLoS One,8(6):e65680

基本信息:

DOI:10.13417/j.gab.039.004171

中图分类号:Q943.2

引用信息:

[1]张驰,王艳芳,陈静,等.植物MYB转录因子调控次生代谢的研究进展[J].基因组学与应用生物学,2020,39(09):4171-4177.DOI:10.13417/j.gab.039.004171.

基金信息:

国家高技术研究发展计划(863计划)项目(2013AA102604-3);; 吉林省发改委-吉林省省级产业创新专项(2016C04;2018C047-3);; 吉林省科技厅自然基金项目(20170101010JC;20180101027JC);吉林省科技厅国际合作项目(201804-14077GH)共同资助

发布时间:

2020-09-25

出版时间:

2020-09-25

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