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由于基因组序列与编码基因之间数目极度不匹配，探究基因组非编码区的潜在功能具有重要意义。转座元件作为基因组非编码区最主要的组成部分，通过转位、顺式调控元件、 RNA与蛋白质产物等多种方式，在DNA、 RNA、蛋白质、三维基因组等多个层面影响宿主基因的生理和病理表达，从而参与肿瘤的发生发展。本文结合近年来前列腺癌方向转座元件相关的研究结果，阐述了前列腺癌基因组工作中的转座元件相关研究部分，并探讨转座元件在前列腺癌临床诊断、临床预后、临床治疗等方面的潜在应用前景。
Abstract：Due to the extreme mismatch between the number of genome sequences and coding genes, it is important to explore the potential functions of non-coding regions of the genome. As the most important component of the non-coding region, transposable elements affect the physiological and pathological expression of host genes through translocation, cis-regulatory elements, RNA and protein pro-ducts at multiple levels such as DNA, RNA, protein and three-dimensional genome, and thus participate in the occurrence and deve-lopment of tumors. Combined with the results of the researches on transposable elements in prostate cancer in recent years, this paper describes the transposon-related part of the prostate cancer genome work, and discusses the potential application prospect of transposon in clinical diagnosis, clinical prognosis, clinical treatment and other aspects of prostate cancer.
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基本信息:
DOI：10.13417/j.gab.043.000561
中图分类号:R737.25
引用信息:
[1]吴子奕,李晶.转座元件在前列腺癌中的研究进展[J].基因组学与应用生物学,2024,43(04):561-568.DOI:10.13417/j.gab.043.000561.
基金信息:
国家重点研发计划青年科学家项目(2022YFA1305700); 国家自然科学基金项目(82022055,82272793)共同资助
2023-12-16
2023-12-16
2023-12-16